Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology
Detection of nonspecific antibodies unrelated to blood group antigen that causes nuisance in pretransfusion testing is a rare event. Their interpretation is often made only after the exclusion of all possible clinically significant antibodies and results in the unnecessary expenditure of reagents an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2018;volume=12;issue=2;spage=169;epage=172;aulast=Kandasamy |
| _version_ | 1818878316193513472 |
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| author | Dhivya Kandasamy Shamee Shastry Deepika Chenna Ganesh Mohan |
| author_facet | Dhivya Kandasamy Shamee Shastry Deepika Chenna Ganesh Mohan |
| author_sort | Dhivya Kandasamy |
| collection | DOAJ |
| description | Detection of nonspecific antibodies unrelated to blood group antigen that causes nuisance in pretransfusion testing is a rare event. Their interpretation is often made only after the exclusion of all possible clinically significant antibodies and results in the unnecessary expenditure of reagents and human resources. We report one such nuisance antibody detected in an antenatal female that showed pan reaction with antibody screening and identification panel red cells including auto control but was compatible with group-specific donor units. Direct antiglobulin test was positive with no hematological evidence of bleeding. Repeat antibody screening test performed after washing the panel red cells and use of panel cells from different manufacturer showed negative reaction raising the suspicion of antibody specificity against chemical constituents in suspension medium of panel cells. Interpretation of nonspecific antibodies as to what they really are demands extensive immunohematological work-up and causes a delay in issue of blood components to the recipient. |
| first_indexed | 2024-12-19T14:12:14Z |
| format | Article |
| id | doaj.art-3ebeb32568b54a189b9d7346c95685f6 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-19T14:12:14Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-3ebeb32568b54a189b9d7346c95685f62022-12-21T20:18:06ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652018-01-0112216917210.4103/ajts.AJTS_100_17Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematologyDhivya KandasamyShamee ShastryDeepika ChennaGanesh MohanDetection of nonspecific antibodies unrelated to blood group antigen that causes nuisance in pretransfusion testing is a rare event. Their interpretation is often made only after the exclusion of all possible clinically significant antibodies and results in the unnecessary expenditure of reagents and human resources. We report one such nuisance antibody detected in an antenatal female that showed pan reaction with antibody screening and identification panel red cells including auto control but was compatible with group-specific donor units. Direct antiglobulin test was positive with no hematological evidence of bleeding. Repeat antibody screening test performed after washing the panel red cells and use of panel cells from different manufacturer showed negative reaction raising the suspicion of antibody specificity against chemical constituents in suspension medium of panel cells. Interpretation of nonspecific antibodies as to what they really are demands extensive immunohematological work-up and causes a delay in issue of blood components to the recipient.http://www.ajts.org/article.asp?issn=0973-6247;year=2018;volume=12;issue=2;spage=169;epage=172;aulast=KandasamyImmunohematological work upnuisance antibodiespretransfusion testing |
| spellingShingle | Dhivya Kandasamy Shamee Shastry Deepika Chenna Ganesh Mohan Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology Asian Journal of Transfusion Science Immunohematological work up nuisance antibodies pretransfusion testing |
| title | Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology |
| title_full | Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology |
| title_fullStr | Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology |
| title_full_unstemmed | Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology |
| title_short | Real eyes realizes real lies: A case report and review of nuisance antibodies in immunohematology |
| title_sort | real eyes realizes real lies a case report and review of nuisance antibodies in immunohematology |
| topic | Immunohematological work up nuisance antibodies pretransfusion testing |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2018;volume=12;issue=2;spage=169;epage=172;aulast=Kandasamy |
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