Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy
This review explores the use of energy sources, including ultrasound, magnetic fields, and external beam radiation, to trigger the delivery of drugs from liposomes in a tumor in a spatially-specific manner. Each section explores the mechanism(s) of drug release that can be achieved using liposomes i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-03-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/11/3/125 |
| _version_ | 1811279160606195712 |
|---|---|
| author | Courtney van Ballegooie Alice Man Mi Win Donald T. Yapp |
| author_facet | Courtney van Ballegooie Alice Man Mi Win Donald T. Yapp |
| author_sort | Courtney van Ballegooie |
| collection | DOAJ |
| description | This review explores the use of energy sources, including ultrasound, magnetic fields, and external beam radiation, to trigger the delivery of drugs from liposomes in a tumor in a spatially-specific manner. Each section explores the mechanism(s) of drug release that can be achieved using liposomes in conjunction with the external trigger. Subsequently, the treatment’s formulation factors are discussed, highlighting the parameters of both the therapy and the medical device. Additionally, the pre-clinical and clinical trials of each triggered release method are explored. Lastly, the advantages and disadvantages, as well as the feasibility and future outlook of each triggered release method, are discussed. |
| first_indexed | 2024-04-13T00:48:24Z |
| format | Article |
| id | doaj.art-3ec00a300c8d45008ddfc7d96f7d2dc3 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-13T00:48:24Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3ec00a300c8d45008ddfc7d96f7d2dc32022-12-22T03:09:55ZengMDPI AGPharmaceutics1999-49232019-03-0111312510.3390/pharmaceutics11030125pharmaceutics11030125Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of EnergyCourtney van Ballegooie0Alice Man1Mi Win2Donald T. Yapp3Experimental Therapeutics, BC Cancer, Vancouver, BC V5Z 1L3, CanadaFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, CanadaExperimental Therapeutics, BC Cancer, Vancouver, BC V5Z 1L3, CanadaThis review explores the use of energy sources, including ultrasound, magnetic fields, and external beam radiation, to trigger the delivery of drugs from liposomes in a tumor in a spatially-specific manner. Each section explores the mechanism(s) of drug release that can be achieved using liposomes in conjunction with the external trigger. Subsequently, the treatment’s formulation factors are discussed, highlighting the parameters of both the therapy and the medical device. Additionally, the pre-clinical and clinical trials of each triggered release method are explored. Lastly, the advantages and disadvantages, as well as the feasibility and future outlook of each triggered release method, are discussed.http://www.mdpi.com/1999-4923/11/3/125triggered drug releaseliposomesultrasoundmagnetic fieldsradiation |
| spellingShingle | Courtney van Ballegooie Alice Man Mi Win Donald T. Yapp Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy Pharmaceutics triggered drug release liposomes ultrasound magnetic fields radiation |
| title | Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy |
| title_full | Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy |
| title_fullStr | Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy |
| title_full_unstemmed | Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy |
| title_short | Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy |
| title_sort | spatially specific liposomal cancer therapy triggered by clinical external sources of energy |
| topic | triggered drug release liposomes ultrasound magnetic fields radiation |
| url | http://www.mdpi.com/1999-4923/11/3/125 |
| work_keys_str_mv | AT courtneyvanballegooie spatiallyspecificliposomalcancertherapytriggeredbyclinicalexternalsourcesofenergy AT aliceman spatiallyspecificliposomalcancertherapytriggeredbyclinicalexternalsourcesofenergy AT miwin spatiallyspecificliposomalcancertherapytriggeredbyclinicalexternalsourcesofenergy AT donaldtyapp spatiallyspecificliposomalcancertherapytriggeredbyclinicalexternalsourcesofenergy |