Development of Thiophene Compounds as Potent Chemotherapies for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major

Development of Thiophene Compounds as Potent Chemotherapies for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major

Leishmania major (L. major) is a protozoan parasite that causes cutaneous leishmaniasis. About 12 million people are currently infected with an annual incidence of 1.3 million cases. The purpose of this study was to synthesize a small library of novel thiophene derivatives, and evaluate its parasiti...

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Bibliographic Details
Main Authors: Felipe Rodriguez, Eva Iniguez, Guadalupe Pena Contreras, Haidar Ahmed, Thadeu E. M. M. Costa, Rachid Skouta, Rosa A. Maldonado
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
thiophene compounds
Leishmania major
cutaneous leishmaniasis
drug screening
chemotherapy
structure–activity relationship (SAR)
in silico docking
reactive oxygen species
Online Access:http://www.mdpi.com/1420-3049/23/7/1626

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