Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat
Background Both intra-abdominal fat (IAF) and high-density lipoprotein cholesterol (HDL-C) are known to be associated with cardiometabolic health. We evaluated whether the accumulation of computed tomography (CT)-measured IAF over 5 years was related to baseline HDL-C concentration in a prospective...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2021-08-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-1130.pdf |
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| author | Sun Ok Song You-Cheol Hwang Han Uk Ryu Steven E. Kahn Donna L. Leonetti Wilfred Y. Fujimoto Edward J. Boyko |
| author_facet | Sun Ok Song You-Cheol Hwang Han Uk Ryu Steven E. Kahn Donna L. Leonetti Wilfred Y. Fujimoto Edward J. Boyko |
| author_sort | Sun Ok Song |
| collection | DOAJ |
| description | Background Both intra-abdominal fat (IAF) and high-density lipoprotein cholesterol (HDL-C) are known to be associated with cardiometabolic health. We evaluated whether the accumulation of computed tomography (CT)-measured IAF over 5 years was related to baseline HDL-C concentration in a prospective cohort study. Methods All participants were Japanese-Americans between the ages of 34 and 74 years. Plasma HDL-C concentration and CT measurements of IAF, abdominal subcutaneous fat (SCF), and thigh SCF cross-sectional areas were assessed at baseline and at 5-year follow-up visits. Results A total of 397 subjects without diabetes were included. The mean±standard deviation HDL-C concentration was 51.6±13.0 mg/dL in men and 66.0±17.0 mg/dL in women, and the IAF was 91.9±48.4 cm2 in men and 63.1±39.5 cm2 in women. The baseline plasma concentration of HDL-C was inversely associated with the change in IAF over 5 years using multivariable regression analysis with adjustment for age, sex, family history of diabetes, weight change over 5 years, and baseline measurements of body mass index, IAF, abdominal SCF, abdominal circumference, thigh SCF, and homeostatic model assessment for insulin resistance. Conclusion These results demonstrate that HDL-C concentration significantly predicts future accumulation of IAF over 5 years independent of age, sex, insulin sensitivity, and body composition in Japanese-American men and women without diabetes. |
| first_indexed | 2024-04-13T15:41:58Z |
| format | Article |
| id | doaj.art-3ec06b23aee94c73bdcf7736e7b4b3b5 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-13T15:41:58Z |
| publishDate | 2021-08-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-3ec06b23aee94c73bdcf7736e7b4b3b52022-12-22T02:41:07ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782021-08-0136483584410.3803/EnM.2021.11302210Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal FatSun Ok Song0You-Cheol Hwang1Han Uk Ryu2Steven E. Kahn3Donna L. Leonetti4Wilfred Y. Fujimoto5Edward J. Boyko6 Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea Department of Neurology, Jeonbuk National University Medical School, Jeonju, Korea Hospital and Specialty Medicine Service, VA Puget Sound Health Care System, Seattle, WA, USA Department of Anthropology, University of Washington, Seattle, WA, USA Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USABackground Both intra-abdominal fat (IAF) and high-density lipoprotein cholesterol (HDL-C) are known to be associated with cardiometabolic health. We evaluated whether the accumulation of computed tomography (CT)-measured IAF over 5 years was related to baseline HDL-C concentration in a prospective cohort study. Methods All participants were Japanese-Americans between the ages of 34 and 74 years. Plasma HDL-C concentration and CT measurements of IAF, abdominal subcutaneous fat (SCF), and thigh SCF cross-sectional areas were assessed at baseline and at 5-year follow-up visits. Results A total of 397 subjects without diabetes were included. The mean±standard deviation HDL-C concentration was 51.6±13.0 mg/dL in men and 66.0±17.0 mg/dL in women, and the IAF was 91.9±48.4 cm2 in men and 63.1±39.5 cm2 in women. The baseline plasma concentration of HDL-C was inversely associated with the change in IAF over 5 years using multivariable regression analysis with adjustment for age, sex, family history of diabetes, weight change over 5 years, and baseline measurements of body mass index, IAF, abdominal SCF, abdominal circumference, thigh SCF, and homeostatic model assessment for insulin resistance. Conclusion These results demonstrate that HDL-C concentration significantly predicts future accumulation of IAF over 5 years independent of age, sex, insulin sensitivity, and body composition in Japanese-American men and women without diabetes.http://www.e-enm.org/upload/pdf/enm-2021-1130.pdfintra-abdominal fatcholesterolhdlepidemiologyasian americans |
| spellingShingle | Sun Ok Song You-Cheol Hwang Han Uk Ryu Steven E. Kahn Donna L. Leonetti Wilfred Y. Fujimoto Edward J. Boyko Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat Endocrinology and Metabolism intra-abdominal fat cholesterol hdl epidemiology asian americans |
| title | Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat |
| title_full | Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat |
| title_fullStr | Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat |
| title_full_unstemmed | Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat |
| title_short | Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat |
| title_sort | lower high density lipoprotein cholesterol concentration is independently associated with greater future accumulation of intra abdominal fat |
| topic | intra-abdominal fat cholesterol hdl epidemiology asian americans |
| url | http://www.e-enm.org/upload/pdf/enm-2021-1130.pdf |
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