Opsins as main regulators of skin biology
Opsins are light-sensitive proteins that are found across the animal kingdom. In mammals, opsins are classically associated with image-forming processes, a function exerted by cone and rod opsins. In early 2000, melanopsin was identified in the human retina as an important regulator of non-image for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of Photochemistry and Photobiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666469023000271 |
| _version_ | 1797798592329547776 |
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| author | Ana Maria de Lauro Castrucci Maurício S. Baptista Leonardo Vinicius Monteiro de Assis |
| author_facet | Ana Maria de Lauro Castrucci Maurício S. Baptista Leonardo Vinicius Monteiro de Assis |
| author_sort | Ana Maria de Lauro Castrucci |
| collection | DOAJ |
| description | Opsins are light-sensitive proteins that are found across the animal kingdom. In mammals, opsins are classically associated with image-forming processes, a function exerted by cone and rod opsins. In early 2000, melanopsin was identified in the human retina as an important regulator of non-image forming events such as melatonin suppression, pupillary constriction, and circadian rhythm adjustment. The presence of different opsins and the biological processes that these proteins regulate in the skin are increasingly being described. Currently, opsins are considered light as well as thermosensors in the skin. However, additional regulatory functions, in a light and thermo-independent fashion, mostly likely via protein-protein interaction have set a new field of study. The goal of this review is to critically revise the literature on the role of opsins in skin physiology as well as in melanoma cancer. |
| first_indexed | 2024-03-13T04:06:07Z |
| format | Article |
| id | doaj.art-3ec2640c2bbc4b17ba8549674f4dc529 |
| institution | Directory Open Access Journal |
| issn | 2666-4690 |
| language | English |
| last_indexed | 2024-03-13T04:06:07Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Photochemistry and Photobiology |
| spelling | doaj.art-3ec2640c2bbc4b17ba8549674f4dc5292023-06-21T07:00:32ZengElsevierJournal of Photochemistry and Photobiology2666-46902023-06-0115100186Opsins as main regulators of skin biologyAna Maria de Lauro Castrucci0Maurício S. Baptista1Leonardo Vinicius Monteiro de Assis2Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil; Department of Biology, University of Virginia, Virginia, United States of AmericaDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, BrazilCenter of Brain, Behavior and Metabolism, Institute of Neurobiology, University of Lübeck, Lübeck, Germany; Corresponding author at: Center of Brain, Behavior and Metabolism, University of Lübeck, Institute of Neurobiology, Marie Curie Street, 23562 Lübeck, Germany.Opsins are light-sensitive proteins that are found across the animal kingdom. In mammals, opsins are classically associated with image-forming processes, a function exerted by cone and rod opsins. In early 2000, melanopsin was identified in the human retina as an important regulator of non-image forming events such as melatonin suppression, pupillary constriction, and circadian rhythm adjustment. The presence of different opsins and the biological processes that these proteins regulate in the skin are increasingly being described. Currently, opsins are considered light as well as thermosensors in the skin. However, additional regulatory functions, in a light and thermo-independent fashion, mostly likely via protein-protein interaction have set a new field of study. The goal of this review is to critically revise the literature on the role of opsins in skin physiology as well as in melanoma cancer.http://www.sciencedirect.com/science/article/pii/S2666469023000271Visible lightSkin biologyPhotosensitive systemSkin cancerMelanoma |
| spellingShingle | Ana Maria de Lauro Castrucci Maurício S. Baptista Leonardo Vinicius Monteiro de Assis Opsins as main regulators of skin biology Journal of Photochemistry and Photobiology Visible light Skin biology Photosensitive system Skin cancer Melanoma |
| title | Opsins as main regulators of skin biology |
| title_full | Opsins as main regulators of skin biology |
| title_fullStr | Opsins as main regulators of skin biology |
| title_full_unstemmed | Opsins as main regulators of skin biology |
| title_short | Opsins as main regulators of skin biology |
| title_sort | opsins as main regulators of skin biology |
| topic | Visible light Skin biology Photosensitive system Skin cancer Melanoma |
| url | http://www.sciencedirect.com/science/article/pii/S2666469023000271 |
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