Advances in diffuse glial tumors diagnosis
In recent decades, there have been significant advances in the diagnosis of diffuse gliomas, driven by the integration of novel technologies. These advancements have deepened our understanding of tumor oncogenesis, enabling a more refined stratification of the biological behavior of these neoplasms....
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2023-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777729 |
| _version_ | 1797372140035506176 |
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| author | Luis Filipe de Souza Godoy Vitor Ribeiro Paes Aline Sgnolf Ayres Gabriela Alencar Bandeira Raquel Andrade Moreno Fabiana de Campos Cordeiro Hirata Frederico Adolfo Benevides Silva Felipe Nascimento Guilherme de Carvalho Campos Neto Andre Felix Gentil Leandro Tavares Lucato Edson Amaro Junior Robert J. Young Suzana Maria Fleury Malheiros |
| author_facet | Luis Filipe de Souza Godoy Vitor Ribeiro Paes Aline Sgnolf Ayres Gabriela Alencar Bandeira Raquel Andrade Moreno Fabiana de Campos Cordeiro Hirata Frederico Adolfo Benevides Silva Felipe Nascimento Guilherme de Carvalho Campos Neto Andre Felix Gentil Leandro Tavares Lucato Edson Amaro Junior Robert J. Young Suzana Maria Fleury Malheiros |
| author_sort | Luis Filipe de Souza Godoy |
| collection | DOAJ |
| description | In recent decades, there have been significant advances in the diagnosis of diffuse gliomas, driven by the integration of novel technologies. These advancements have deepened our understanding of tumor oncogenesis, enabling a more refined stratification of the biological behavior of these neoplasms. This progress culminated in the fifth edition of the WHO classification of central nervous system (CNS) tumors in 2021. This comprehensive review article aims to elucidate these advances within a multidisciplinary framework, contextualized within the backdrop of the new classification. This article will explore morphologic pathology and molecular/genetics techniques (immunohistochemistry, genetic sequencing, and methylation profiling), which are pivotal in diagnosis, besides the correlation of structural neuroimaging radiophenotypes to pathology and genetics. It briefly reviews the usefulness of tractography and functional neuroimaging in surgical planning. Additionally, the article addresses the value of other functional imaging techniques such as perfusion MRI, spectroscopy, and nuclear medicine in distinguishing tumor progression from treatment-related changes. Furthermore, it discusses the advantages of evolving diagnostic techniques in classifying these tumors, as well as their limitations in terms of availability and utilization. Moreover, the expanding domains of data processing, artificial intelligence, radiomics, and radiogenomics hold great promise and may soon exert a substantial influence on glioma diagnosis. These innovative technologies have the potential to revolutionize our approach to these tumors. Ultimately, this review underscores the fundamental importance of multidisciplinary collaboration in employing recent diagnostic advancements, thereby hoping to translate them into improved quality of life and extended survival for glioma patients. |
| first_indexed | 2024-03-08T18:31:34Z |
| format | Article |
| id | doaj.art-3ec32aff32bd475c863dea990727ea6d |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-03-08T18:31:34Z |
| publishDate | 2023-12-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-3ec32aff32bd475c863dea990727ea6d2023-12-30T00:06:06ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272023-12-0181121134114510.1055/s-0043-1777729Advances in diffuse glial tumors diagnosisLuis Filipe de Souza Godoy0https://orcid.org/0000-0002-6918-6865Vitor Ribeiro Paes1https://orcid.org/0000-0001-8752-5624Aline Sgnolf Ayres2https://orcid.org/0000-0001-5042-4897Gabriela Alencar Bandeira3https://orcid.org/0000-0002-9605-1915Raquel Andrade Moreno4https://orcid.org/0000-0002-7729-7418Fabiana de Campos Cordeiro Hirata5https://orcid.org/0000-0003-3941-2574Frederico Adolfo Benevides Silva6https://orcid.org/0000-0001-9817-5949Felipe Nascimento7https://orcid.org/0000-0003-4319-3386Guilherme de Carvalho Campos Neto8https://orcid.org/0000-0002-6324-3371Andre Felix Gentil9https://orcid.org/0000-0002-5228-2033Leandro Tavares Lucato10https://orcid.org/0000-0001-9181-5245Edson Amaro Junior11https://orcid.org/0000-0002-5889-1382Robert J. Young12https://orcid.org/0000-0001-7003-3017Suzana Maria Fleury Malheiros13https://orcid.org/0000-0003-3433-6867Hospital Israelita Albert Einstein, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.Hospital Israelita Albert Einstein, Laboratório de Patologia Cirúrgica, São Paulo SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Seção de Neuroradiologia, São Paulo SP, Brazil.Instituto do Câncer do Estado de São Paulo, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.Instituto do Câncer do Estado de São Paulo, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.Hospital Israelita Albert Einstein, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.Hospital Israelita Albert Einstein, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.Hospital Israelita Albert Einstein, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.Hospital Israelita Albert Einstein, Departamento de Radiologia, Seção de Medicina Nuclear, São Paulo SP, Brazil.Hospital Israelita Albert Einstein, Departamento de Neurocirurgia, São Paulo SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Seção de Neuroradiologia, São Paulo SP, Brazil.Hospital Israelita Albert Einstein, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.Memorial Sloan-Kettering Cancer Center, Neuroradiology Service, New York, New York, United States.Hospital Israelita Albert Einstein, Departamento de Oncologia, Seção de Neuro-Oncologia, São Paulo SP, Brazil.In recent decades, there have been significant advances in the diagnosis of diffuse gliomas, driven by the integration of novel technologies. These advancements have deepened our understanding of tumor oncogenesis, enabling a more refined stratification of the biological behavior of these neoplasms. This progress culminated in the fifth edition of the WHO classification of central nervous system (CNS) tumors in 2021. This comprehensive review article aims to elucidate these advances within a multidisciplinary framework, contextualized within the backdrop of the new classification. This article will explore morphologic pathology and molecular/genetics techniques (immunohistochemistry, genetic sequencing, and methylation profiling), which are pivotal in diagnosis, besides the correlation of structural neuroimaging radiophenotypes to pathology and genetics. It briefly reviews the usefulness of tractography and functional neuroimaging in surgical planning. Additionally, the article addresses the value of other functional imaging techniques such as perfusion MRI, spectroscopy, and nuclear medicine in distinguishing tumor progression from treatment-related changes. Furthermore, it discusses the advantages of evolving diagnostic techniques in classifying these tumors, as well as their limitations in terms of availability and utilization. Moreover, the expanding domains of data processing, artificial intelligence, radiomics, and radiogenomics hold great promise and may soon exert a substantial influence on glioma diagnosis. These innovative technologies have the potential to revolutionize our approach to these tumors. Ultimately, this review underscores the fundamental importance of multidisciplinary collaboration in employing recent diagnostic advancements, thereby hoping to translate them into improved quality of life and extended survival for glioma patients.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777729GliomaNeuroimagingBiomarkersGenetic ProfilePathologyPrecision MedicineMachine LearningGliomaNeuroimagemBiomarcadoresPerfil GenéticoPatologiaMedicina de PrecisãoAprendizado de Máquina |
| spellingShingle | Luis Filipe de Souza Godoy Vitor Ribeiro Paes Aline Sgnolf Ayres Gabriela Alencar Bandeira Raquel Andrade Moreno Fabiana de Campos Cordeiro Hirata Frederico Adolfo Benevides Silva Felipe Nascimento Guilherme de Carvalho Campos Neto Andre Felix Gentil Leandro Tavares Lucato Edson Amaro Junior Robert J. Young Suzana Maria Fleury Malheiros Advances in diffuse glial tumors diagnosis Arquivos de Neuro-Psiquiatria Glioma Neuroimaging Biomarkers Genetic Profile Pathology Precision Medicine Machine Learning Glioma Neuroimagem Biomarcadores Perfil Genético Patologia Medicina de Precisão Aprendizado de Máquina |
| title | Advances in diffuse glial tumors diagnosis |
| title_full | Advances in diffuse glial tumors diagnosis |
| title_fullStr | Advances in diffuse glial tumors diagnosis |
| title_full_unstemmed | Advances in diffuse glial tumors diagnosis |
| title_short | Advances in diffuse glial tumors diagnosis |
| title_sort | advances in diffuse glial tumors diagnosis |
| topic | Glioma Neuroimaging Biomarkers Genetic Profile Pathology Precision Medicine Machine Learning Glioma Neuroimagem Biomarcadores Perfil Genético Patologia Medicina de Precisão Aprendizado de Máquina |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777729 |
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