Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review
Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/4/191 |
| _version_ | 1797605915016298496 |
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| author | Agnieszka Kalita Magdalena Sikora-Skrabaka Ewa Nowakowska-Zajdel |
| author_facet | Agnieszka Kalita Magdalena Sikora-Skrabaka Ewa Nowakowska-Zajdel |
| author_sort | Agnieszka Kalita |
| collection | DOAJ |
| description | Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogenesis. MicroRNAs are small single-stranded non-coding RNAs that take part in the post-transcriptional regulation of gene expression. Some ADAM proteins can be targets for microRNAs. In this review, we analyze the impact of microRNA/ADAM protein axes in GI cancers. |
| first_indexed | 2024-03-11T05:07:51Z |
| format | Article |
| id | doaj.art-3ec36deb31464c8cb36ddf9fcefe141a |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T05:07:51Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-3ec36deb31464c8cb36ddf9fcefe141a2023-11-17T18:47:33ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-04-014542917293610.3390/cimb45040191Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A ReviewAgnieszka Kalita0Magdalena Sikora-Skrabaka1Ewa Nowakowska-Zajdel2Department of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, PolandDepartment of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, PolandDepartment of Nutrition-Related Disease Prevention, Department of Metabolic Disease Prevention, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, PolandGastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogenesis. MicroRNAs are small single-stranded non-coding RNAs that take part in the post-transcriptional regulation of gene expression. Some ADAM proteins can be targets for microRNAs. In this review, we analyze the impact of microRNA/ADAM protein axes in GI cancers.https://www.mdpi.com/1467-3045/45/4/191gastrointestinal cancersmicroRNA/miRADAM proteinsbiomarkers |
| spellingShingle | Agnieszka Kalita Magdalena Sikora-Skrabaka Ewa Nowakowska-Zajdel Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review Current Issues in Molecular Biology gastrointestinal cancers microRNA/miR ADAM proteins biomarkers |
| title | Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review |
| title_full | Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review |
| title_fullStr | Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review |
| title_full_unstemmed | Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review |
| title_short | Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review |
| title_sort | role of some microrna adam proteins axes in gastrointestinal cancers as a novel biomarkers and potential therapeutic targets a review |
| topic | gastrointestinal cancers microRNA/miR ADAM proteins biomarkers |
| url | https://www.mdpi.com/1467-3045/45/4/191 |
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