Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease
Neuroinflammation is a common feature in Alzheimer’s (AD) and Parkinson’s (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations in the crosstalk between glial cells and neurons. Here...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/9/1094 |
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| author | Víctor Antonio Blanco-Palmero Marcos Rubio-Fernández Desireé Antequera Alberto Villarejo-Galende José Antonio Molina Isidro Ferrer Fernando Bartolome Eva Carro |
| author_facet | Víctor Antonio Blanco-Palmero Marcos Rubio-Fernández Desireé Antequera Alberto Villarejo-Galende José Antonio Molina Isidro Ferrer Fernando Bartolome Eva Carro |
| author_sort | Víctor Antonio Blanco-Palmero |
| collection | DOAJ |
| description | Neuroinflammation is a common feature in Alzheimer’s (AD) and Parkinson’s (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations in the crosstalk between glial cells and neurons. Here, we tried to clarify the pattern of two of the most promising biomarkers of neuroinflammation in cerebrospinal fluid (CSF) in AD and PD. This study included cognitively unimpaired elderly patients, patients with mild cognitive impairment, patients with AD dementia, and patients with PD. CSF samples were analyzed for YKL-40 and C-reactive protein (CRP). We found that CSF YKL-40 levels were significantly increased only in dementia stages of AD. Additionally, increased YKL-40 levels were found in the cerebral orbitofrontal cortex from AD patients in agreement with augmented astrogliosis. Our study confirms that these biomarkers of neuroinflammation are differently detected in CSF from AD and PD patients. |
| first_indexed | 2024-03-10T07:53:05Z |
| format | Article |
| id | doaj.art-3ec417ac598c44d58683dbd256fa4a56 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T07:53:05Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-3ec417ac598c44d58683dbd256fa4a562023-11-22T12:06:55ZengMDPI AGBiomedicines2227-90592021-08-0199109410.3390/biomedicines9091094Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s DiseaseVíctor Antonio Blanco-Palmero0Marcos Rubio-Fernández1Desireé Antequera2Alberto Villarejo-Galende3José Antonio Molina4Isidro Ferrer5Fernando Bartolome6Eva Carro7Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, SpainNeuroinflammation is a common feature in Alzheimer’s (AD) and Parkinson’s (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations in the crosstalk between glial cells and neurons. Here, we tried to clarify the pattern of two of the most promising biomarkers of neuroinflammation in cerebrospinal fluid (CSF) in AD and PD. This study included cognitively unimpaired elderly patients, patients with mild cognitive impairment, patients with AD dementia, and patients with PD. CSF samples were analyzed for YKL-40 and C-reactive protein (CRP). We found that CSF YKL-40 levels were significantly increased only in dementia stages of AD. Additionally, increased YKL-40 levels were found in the cerebral orbitofrontal cortex from AD patients in agreement with augmented astrogliosis. Our study confirms that these biomarkers of neuroinflammation are differently detected in CSF from AD and PD patients.https://www.mdpi.com/2227-9059/9/9/1094Alzheimer’s diseaseParkinson’s diseaseYKL-40C-reactive proteinCSF and plasma biomarkersinflammation |
| spellingShingle | Víctor Antonio Blanco-Palmero Marcos Rubio-Fernández Desireé Antequera Alberto Villarejo-Galende José Antonio Molina Isidro Ferrer Fernando Bartolome Eva Carro Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease Biomedicines Alzheimer’s disease Parkinson’s disease YKL-40 C-reactive protein CSF and plasma biomarkers inflammation |
| title | Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease |
| title_full | Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease |
| title_fullStr | Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease |
| title_full_unstemmed | Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease |
| title_short | Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease |
| title_sort | increased ykl 40 but not c reactive protein levels in patients with alzheimer s disease |
| topic | Alzheimer’s disease Parkinson’s disease YKL-40 C-reactive protein CSF and plasma biomarkers inflammation |
| url | https://www.mdpi.com/2227-9059/9/9/1094 |
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