Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity

Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity

Telomerase activity is elevated in most cancer cells and is required for telomere length maintenance and immortalization of cancer cells. Glucose metabolic reprogramming is a hallmark of cancer and accompanied with increased expression of key metabolic enzymes. Whether these enzymes influence telome...

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Bibliographic Details
Main Authors: Ruiguan Wang, Jiangbo Li, Changjian Zhang, Xin Guan, Boyu Qin, Rui Jin, Lingmei Qin, Shanrong Xu, Xiaona Zhang, Rong Liu, Qinong Ye, Long Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
LDHB
telomerase
telomere
pancreatic cancer
cell senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.821620/full

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