Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review
Adipose-derived stem cells comprise several clinically beneficial qualities that have been explored in basic research and have motivated several clinical studies with promising results. After being approved in the European Union, UK, Switzerland, Israel, and Japan, allogeneic adipose-derived stem ce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/11/2338 |
| _version_ | 1827645771641520128 |
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| author | Tihomir Georgiev-Hristov Mariano García-Arranz Jacobo Trébol-López Paula Barba-Recreo Damián García-Olmo |
| author_facet | Tihomir Georgiev-Hristov Mariano García-Arranz Jacobo Trébol-López Paula Barba-Recreo Damián García-Olmo |
| author_sort | Tihomir Georgiev-Hristov |
| collection | DOAJ |
| description | Adipose-derived stem cells comprise several clinically beneficial qualities that have been explored in basic research and have motivated several clinical studies with promising results. After being approved in the European Union, UK, Switzerland, Israel, and Japan, allogeneic adipose-derived stem cells (darvadstrocel) have been recently granted a regenerative medicine advanced therapy (RMAT) designation by US FDA for complex perianal fistulas in adults with Crohn’s disease. This huge scientific step is likely to impact the future spread of the indications of allogeneic adipose-derived stem cell applications. The current knowledge on adipose stem cell harvest describes quantitative and qualitative differences that could be influenced by different donor conditions and donor sites. In this comprehensive review, we summarize the current knowledge on the topic and propose donor profiles that could provide the optimal initial quality of this living drug, as a starting point for further applications and studies in different pathological conditions. |
| first_indexed | 2024-03-09T18:44:52Z |
| format | Article |
| id | doaj.art-3ec9069af4d44a13974457c273066b59 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T18:44:52Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3ec9069af4d44a13974457c273066b592023-11-24T06:20:36ZengMDPI AGPharmaceutics1999-49232022-10-011411233810.3390/pharmaceutics14112338Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive ReviewTihomir Georgiev-Hristov0Mariano García-Arranz1Jacobo Trébol-López2Paula Barba-Recreo3Damián García-Olmo4Servicio de Cirugía General y del Aparato Digestivo, Hospital General Universitario de Villalba, 28400 Madrid, SpainInstituto de Investigación Sanitaria, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, SpainServicio de Cirugía General y del Aparato Digestivo, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, SpainFacultad de Medicina, Universidad Alfonso X, 28691 Madrid, SpainInstituto de Investigación Sanitaria, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, SpainAdipose-derived stem cells comprise several clinically beneficial qualities that have been explored in basic research and have motivated several clinical studies with promising results. After being approved in the European Union, UK, Switzerland, Israel, and Japan, allogeneic adipose-derived stem cells (darvadstrocel) have been recently granted a regenerative medicine advanced therapy (RMAT) designation by US FDA for complex perianal fistulas in adults with Crohn’s disease. This huge scientific step is likely to impact the future spread of the indications of allogeneic adipose-derived stem cell applications. The current knowledge on adipose stem cell harvest describes quantitative and qualitative differences that could be influenced by different donor conditions and donor sites. In this comprehensive review, we summarize the current knowledge on the topic and propose donor profiles that could provide the optimal initial quality of this living drug, as a starting point for further applications and studies in different pathological conditions.https://www.mdpi.com/1999-4923/14/11/2338adipose-derived stem cellsstem cell donorallogenic stem cells |
| spellingShingle | Tihomir Georgiev-Hristov Mariano García-Arranz Jacobo Trébol-López Paula Barba-Recreo Damián García-Olmo Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review Pharmaceutics adipose-derived stem cells stem cell donor allogenic stem cells |
| title | Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review |
| title_full | Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review |
| title_fullStr | Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review |
| title_full_unstemmed | Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review |
| title_short | Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review |
| title_sort | searching for the optimal donor for allogenic adipose derived stem cells a comprehensive review |
| topic | adipose-derived stem cells stem cell donor allogenic stem cells |
| url | https://www.mdpi.com/1999-4923/14/11/2338 |
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