Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields
Background Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated. Methods We prospectively enrolled subjects admitted to pulmonology clinics. We collected exhaled breath condensates (EBC) and analysed the levels of six and 12 bio...
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The Korean Academy of Tuberculosis and Respiratory Diseases
2024-01-01
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| Series: | Tuberculosis and Respiratory Diseases |
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| Online Access: | http://e-trd.org/upload/pdf/trd-2023-0028.pdf |
| _version_ | 1827394025955524608 |
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| author | Yong Jun Choi Min Jae Lee Min Kwang Byun Sangho Park Jimyung Park Dongil Park Sang-Hoon Kim Youngsam Kim Seong Yong Lim Kwang Ha Yoo Ki Suck Jung Hye Jung Park |
| author_facet | Yong Jun Choi Min Jae Lee Min Kwang Byun Sangho Park Jimyung Park Dongil Park Sang-Hoon Kim Youngsam Kim Seong Yong Lim Kwang Ha Yoo Ki Suck Jung Hye Jung Park |
| author_sort | Yong Jun Choi |
| collection | DOAJ |
| description | Background Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated. Methods We prospectively enrolled subjects admitted to pulmonology clinics. We collected exhaled breath condensates (EBC) and analysed the levels of six and 12 biomarkers using conventional and multiplex enzyme-linked immunosorbent assay, respectively. Results Among the 123 subjects, healthy controls constituted the largest group (81 participants; 65.9%), followed by the preserved ratio impaired spirometry group (21 patients; 17.1%) and the chronic obstructive pulmonary disease (COPD) group (21 patients; 17.1%). In COPD patients, platelet derived growth factor-AA exhibited strong positive correlations with COPD assessment test (ρ=0.5926, p=0.0423) and COPD-specific version of St. George’s Respiratory Questionnaire (SGRQ-C) score (total, ρ=0.6725, p=0.0166; activity, ρ=0.7176, p=0.0086; and impacts, ρ=0.6151, p=0.0333). Granzyme B showed strong positive correlations with SGRQ-C score (symptoms, ρ=0.6078, p=0.0360; and impacts, ρ=0.6007, p=0.0389). Interleukin 6 exhibited a strong positive correlation with SGRQ-C score (activity, ρ=0.4671, p=0.0378). The absolute serum eosinophil and basophil counts showed positive correlations with pro-collagen I alpha 1 (ρ=0.6735, p=0.0164 and ρ=0.6295, p=0.0283, respectively). In healthy subjects, forced expiratory volume in 1 second (FEV1)/forced vital capacity demonstrated significant correlation with CC chemokine ligand 3 (CCL3)/macrophage inflammatory protein 1 alpha (ρ=0.3897 and p=0.0068). FEV1 exhibited significant correlation with CCL11/eotaxin (ρ=0.4445 and p=0.0017). Conclusion Inflammatory biomarkers in EBC might be useful to predict quality of life concerning respiratory symptoms and serologic markers. Further studies are needed. |
| first_indexed | 2024-03-08T18:01:06Z |
| format | Article |
| id | doaj.art-3ecc31af117749cfbdfa255803fde284 |
| institution | Directory Open Access Journal |
| issn | 1738-3536 2005-6184 |
| language | English |
| last_indexed | 2024-03-08T18:01:06Z |
| publishDate | 2024-01-01 |
| publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
| record_format | Article |
| series | Tuberculosis and Respiratory Diseases |
| spelling | doaj.art-3ecc31af117749cfbdfa255803fde2842024-01-02T01:02:19ZengThe Korean Academy of Tuberculosis and Respiratory DiseasesTuberculosis and Respiratory Diseases1738-35362005-61842024-01-01871657910.4046/trd.2023.00284839Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical FieldsYong Jun Choi0Min Jae Lee1Min Kwang Byun2Sangho Park3Jimyung Park4Dongil Park5Sang-Hoon Kim6Youngsam Kim7Seong Yong Lim8Kwang Ha Yoo9Ki Suck Jung10Hye Jung Park11 Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Republic of Korea Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea Division of Pulmonary and Allergy, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Republic of Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaBackground Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated. Methods We prospectively enrolled subjects admitted to pulmonology clinics. We collected exhaled breath condensates (EBC) and analysed the levels of six and 12 biomarkers using conventional and multiplex enzyme-linked immunosorbent assay, respectively. Results Among the 123 subjects, healthy controls constituted the largest group (81 participants; 65.9%), followed by the preserved ratio impaired spirometry group (21 patients; 17.1%) and the chronic obstructive pulmonary disease (COPD) group (21 patients; 17.1%). In COPD patients, platelet derived growth factor-AA exhibited strong positive correlations with COPD assessment test (ρ=0.5926, p=0.0423) and COPD-specific version of St. George’s Respiratory Questionnaire (SGRQ-C) score (total, ρ=0.6725, p=0.0166; activity, ρ=0.7176, p=0.0086; and impacts, ρ=0.6151, p=0.0333). Granzyme B showed strong positive correlations with SGRQ-C score (symptoms, ρ=0.6078, p=0.0360; and impacts, ρ=0.6007, p=0.0389). Interleukin 6 exhibited a strong positive correlation with SGRQ-C score (activity, ρ=0.4671, p=0.0378). The absolute serum eosinophil and basophil counts showed positive correlations with pro-collagen I alpha 1 (ρ=0.6735, p=0.0164 and ρ=0.6295, p=0.0283, respectively). In healthy subjects, forced expiratory volume in 1 second (FEV1)/forced vital capacity demonstrated significant correlation with CC chemokine ligand 3 (CCL3)/macrophage inflammatory protein 1 alpha (ρ=0.3897 and p=0.0068). FEV1 exhibited significant correlation with CCL11/eotaxin (ρ=0.4445 and p=0.0017). Conclusion Inflammatory biomarkers in EBC might be useful to predict quality of life concerning respiratory symptoms and serologic markers. Further studies are needed.http://e-trd.org/upload/pdf/trd-2023-0028.pdfexhaled condensateschronic obstructive pulmonary disease, lung function testeosinophils |
| spellingShingle | Yong Jun Choi Min Jae Lee Min Kwang Byun Sangho Park Jimyung Park Dongil Park Sang-Hoon Kim Youngsam Kim Seong Yong Lim Kwang Ha Yoo Ki Suck Jung Hye Jung Park Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields Tuberculosis and Respiratory Diseases exhaled condensates chronic obstructive pulmonary disease, lung function test eosinophils |
| title | Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields |
| title_full | Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields |
| title_fullStr | Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields |
| title_full_unstemmed | Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields |
| title_short | Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields |
| title_sort | roles of inflammatory biomarkers in exhaled breath condensates in respiratory clinical fields |
| topic | exhaled condensates chronic obstructive pulmonary disease, lung function test eosinophils |
| url | http://e-trd.org/upload/pdf/trd-2023-0028.pdf |
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