Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Abstract Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues. Great strides have been made to uncover key regulators of t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-023-00975-7 |
| _version_ | 1827633534075928576 |
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| author | Lei Liu Yanjun Li Guo Chen Quan Chen |
| author_facet | Lei Liu Yanjun Li Guo Chen Quan Chen |
| author_sort | Lei Liu |
| collection | DOAJ |
| description | Abstract Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues. Great strides have been made to uncover key regulators of these complex processes. Emerging evidence has shown that there exists a tight coordination between mitophagy and mitobiogenesis, and their defects may cause many human diseases. In this review, we will first summarize the recent advances made in the discovery of molecular regulations of mitobiogenesis and mitophagy and then focus on the mechanism and signaling pathways involved in the simultaneous regulation of mitobiogenesis and mitophagy in the response of tissue or cultured cells to energy needs, stress, or pathophysiological conditions. Further studies of the crosstalk of these two opposing processes at the molecular level will provide a better understanding of how the cell maintains optimal cellular fitness and function under physiological and pathophysiological conditions, which holds promise for fighting aging and aging-related diseases. |
| first_indexed | 2024-03-09T15:00:52Z |
| format | Article |
| id | doaj.art-3ecc37e92b384b899ffc5db1b5f32ff7 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-03-09T15:00:52Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-3ecc37e92b384b899ffc5db1b5f32ff72023-11-26T13:55:15ZengBMCJournal of Biomedical Science1423-01272023-10-0130111910.1186/s12929-023-00975-7Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasisLei Liu0Yanjun Li1Guo Chen2Quan Chen3Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of SciencesCenter of Cell Response, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai UniversityCenter of Cell Response, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai UniversityCenter of Cell Response, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai UniversityAbstract Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues. Great strides have been made to uncover key regulators of these complex processes. Emerging evidence has shown that there exists a tight coordination between mitophagy and mitobiogenesis, and their defects may cause many human diseases. In this review, we will first summarize the recent advances made in the discovery of molecular regulations of mitobiogenesis and mitophagy and then focus on the mechanism and signaling pathways involved in the simultaneous regulation of mitobiogenesis and mitophagy in the response of tissue or cultured cells to energy needs, stress, or pathophysiological conditions. Further studies of the crosstalk of these two opposing processes at the molecular level will provide a better understanding of how the cell maintains optimal cellular fitness and function under physiological and pathophysiological conditions, which holds promise for fighting aging and aging-related diseases.https://doi.org/10.1186/s12929-023-00975-7Mitochondrial biogenesisMitophagyMitophagy receptorsMitochondrial qualityAgingAging-related diseases |
| spellingShingle | Lei Liu Yanjun Li Guo Chen Quan Chen Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis Journal of Biomedical Science Mitochondrial biogenesis Mitophagy Mitophagy receptors Mitochondrial quality Aging Aging-related diseases |
| title | Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis |
| title_full | Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis |
| title_fullStr | Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis |
| title_full_unstemmed | Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis |
| title_short | Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis |
| title_sort | crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis |
| topic | Mitochondrial biogenesis Mitophagy Mitophagy receptors Mitochondrial quality Aging Aging-related diseases |
| url | https://doi.org/10.1186/s12929-023-00975-7 |
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