Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study
Abstract Background IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and is an important cause of end-stage renal disease (ESRD). Exploring novel biomarkers is necessary for predicting the disease activity and progression of IgAN patients. The present study sought to investigat...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1420-0 |
| _version_ | 1818159060384481280 |
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| author | Tong-dan Bi Jian-nan Zheng Jun-xiao Zhang Long-shu Yang Nan Liu Li Yao Lin-lin Liu |
| author_facet | Tong-dan Bi Jian-nan Zheng Jun-xiao Zhang Long-shu Yang Nan Liu Li Yao Lin-lin Liu |
| author_sort | Tong-dan Bi |
| collection | DOAJ |
| description | Abstract Background IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and is an important cause of end-stage renal disease (ESRD). Exploring novel biomarkers is necessary for predicting the disease activity and progression of IgAN patients. The present study sought to investigate the value of serum C4 for predicting the prognosis of IgAN patients. Methods The primary endpoint of this retrospective study was a composite event of either a ≥ 50% reduction in estimated glomerular filtration rate (eGFR) or end-stage renal disease (ESRD) or death. The associations between serum C4 and clinicopathological parameters and prognosis of this cohort of IgAN patients were evaluated. Results The present study included 1356 IgAN patients. Serum C4 levels correlated significantly with clinical prognostic factors. Serum C4 levels correlated positively with urinary protein excretion (r = 0.307, P < 0.001), and negatively correlated with estimated glomerular filtration rate (r = − 0.281, P < 0.001). Furthermore, serum C4 levels increased with aggravation of tubulointerstitial injury, crescents and ratios of global sclerosis (all P < 0.05). Prognostic analyses with the Cox proportional hazards regression model and Kaplan-Meier survival curves further identified serum C4 as an independent risk factor for the prognosis of IgAN. Conclusions The present study identified serum C4 as a useful predictor for the prognosis of IgAN patients. The mechanism of the trend of serum C4 in IgAN needs to be illustrated in further research. |
| first_indexed | 2024-12-11T15:39:59Z |
| format | Article |
| id | doaj.art-3ecd53af56ae4eafaac538230dd2ac73 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-11T15:39:59Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-3ecd53af56ae4eafaac538230dd2ac732022-12-22T00:59:50ZengBMCBMC Nephrology1471-23692019-07-012011810.1186/s12882-019-1420-0Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective studyTong-dan Bi0Jian-nan Zheng1Jun-xiao Zhang2Long-shu Yang3Nan Liu4Li Yao5Lin-lin Liu6Department of Nephrology, The First Affiliated Hospital of China Medical UniversityDepartment of Nephrology, The First Affiliated Hospital of China Medical UniversityDepartment of Nephrology, The First Affiliated Hospital of China Medical UniversityDepartment of Nephrology, The First Affiliated Hospital of China Medical UniversityDepartment of Nephrology, The First Affiliated Hospital of China Medical UniversityDepartment of Nephrology, The First Affiliated Hospital of China Medical UniversityDepartment of Nephrology, The First Affiliated Hospital of China Medical UniversityAbstract Background IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and is an important cause of end-stage renal disease (ESRD). Exploring novel biomarkers is necessary for predicting the disease activity and progression of IgAN patients. The present study sought to investigate the value of serum C4 for predicting the prognosis of IgAN patients. Methods The primary endpoint of this retrospective study was a composite event of either a ≥ 50% reduction in estimated glomerular filtration rate (eGFR) or end-stage renal disease (ESRD) or death. The associations between serum C4 and clinicopathological parameters and prognosis of this cohort of IgAN patients were evaluated. Results The present study included 1356 IgAN patients. Serum C4 levels correlated significantly with clinical prognostic factors. Serum C4 levels correlated positively with urinary protein excretion (r = 0.307, P < 0.001), and negatively correlated with estimated glomerular filtration rate (r = − 0.281, P < 0.001). Furthermore, serum C4 levels increased with aggravation of tubulointerstitial injury, crescents and ratios of global sclerosis (all P < 0.05). Prognostic analyses with the Cox proportional hazards regression model and Kaplan-Meier survival curves further identified serum C4 as an independent risk factor for the prognosis of IgAN. Conclusions The present study identified serum C4 as a useful predictor for the prognosis of IgAN patients. The mechanism of the trend of serum C4 in IgAN needs to be illustrated in further research.http://link.springer.com/article/10.1186/s12882-019-1420-0Complement C4IgA nephropathyBiomarkerPrognosis |
| spellingShingle | Tong-dan Bi Jian-nan Zheng Jun-xiao Zhang Long-shu Yang Nan Liu Li Yao Lin-lin Liu Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study BMC Nephrology Complement C4 IgA nephropathy Biomarker Prognosis |
| title | Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study |
| title_full | Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study |
| title_fullStr | Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study |
| title_full_unstemmed | Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study |
| title_short | Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study |
| title_sort | serum complement c4 is an important prognostic factor for iga nephropathy a retrospective study |
| topic | Complement C4 IgA nephropathy Biomarker Prognosis |
| url | http://link.springer.com/article/10.1186/s12882-019-1420-0 |
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