Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time
A small phylogenetically conserved sequence of 11,231 bp, termed FAM247, is repeated in human chromosome 22 by segmental duplications. This sequence forms part of diverse genes that span evolutionary time, the protein genes being the earliest as they are present in zebrafish and/or mice genomes, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/6/3/36 |
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| author | Nicholas Delihas |
| author_facet | Nicholas Delihas |
| author_sort | Nicholas Delihas |
| collection | DOAJ |
| description | A small phylogenetically conserved sequence of 11,231 bp, termed FAM247, is repeated in human chromosome 22 by segmental duplications. This sequence forms part of diverse genes that span evolutionary time, the protein genes being the earliest as they are present in zebrafish and/or mice genomes, and the long noncoding RNA genes and pseudogenes the most recent as they appear to be present only in the human genome. We propose that the conserved sequence provides a nucleation site for new gene development at evolutionarily conserved chromosomal loci where the FAM247 sequences reside. The FAM247 sequence also carries information in its open reading frames that provides protein exon amino acid sequences; one exon plays an integral role in immune system regulation, specifically, the function of ubiquitin-specific protease (USP18) in the regulation of interferon. An analysis of this multifaceted sequence and the genesis of genes that contain it is presented. |
| first_indexed | 2024-03-10T16:36:39Z |
| format | Article |
| id | doaj.art-3ecdf029b3c3414db54fc4a98aa368eb |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-10T16:36:39Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-3ecdf029b3c3414db54fc4a98aa368eb2023-11-20T12:22:45ZengMDPI AGNon-Coding RNA2311-553X2020-09-01633610.3390/ncrna6030036Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary TimeNicholas Delihas0Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, NY 11794-5222, USAA small phylogenetically conserved sequence of 11,231 bp, termed FAM247, is repeated in human chromosome 22 by segmental duplications. This sequence forms part of diverse genes that span evolutionary time, the protein genes being the earliest as they are present in zebrafish and/or mice genomes, and the long noncoding RNA genes and pseudogenes the most recent as they appear to be present only in the human genome. We propose that the conserved sequence provides a nucleation site for new gene development at evolutionarily conserved chromosomal loci where the FAM247 sequences reside. The FAM247 sequence also carries information in its open reading frames that provides protein exon amino acid sequences; one exon plays an integral role in immune system regulation, specifically, the function of ubiquitin-specific protease (USP18) in the regulation of interferon. An analysis of this multifaceted sequence and the genesis of genes that contain it is presented.https://www.mdpi.com/2311-553X/6/3/36de novo gene birthgene evolutionprotogenelong noncoding RNA genespseudogenes<i>USP18</i> |
| spellingShingle | Nicholas Delihas Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time Non-Coding RNA de novo gene birth gene evolution protogene long noncoding RNA genes pseudogenes <i>USP18</i> |
| title | Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time |
| title_full | Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time |
| title_fullStr | Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time |
| title_full_unstemmed | Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time |
| title_short | Genesis of Non-Coding RNA Genes in Human Chromosome 22—A Sequence Connection with Protein Genes Separated by Evolutionary Time |
| title_sort | genesis of non coding rna genes in human chromosome 22 a sequence connection with protein genes separated by evolutionary time |
| topic | de novo gene birth gene evolution protogene long noncoding RNA genes pseudogenes <i>USP18</i> |
| url | https://www.mdpi.com/2311-553X/6/3/36 |
| work_keys_str_mv | AT nicholasdelihas genesisofnoncodingrnagenesinhumanchromosome22asequenceconnectionwithproteingenesseparatedbyevolutionarytime |