Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia
Introduction: The vasculitis ANCAS positive, are a group of diseases with different clinical manifestations. Therapeutic plasma exchange has become an excellent tool for the treatment of these patients in specific conditions. Objective: Describe the demographic and clinical characteristics of pati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Asociación Colombiana de Nefrología e Hipertensión Arterial
2014-05-01
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| Series: | Revista Colombiana de Nefrología |
| Subjects: | |
| Online Access: | http://www.revistanefrologia.org/index.php/rcn/article/view/167/pdf |
| Summary: | Introduction: The vasculitis ANCAS positive, are a group of diseases with different clinical manifestations.
Therapeutic plasma exchange has become an excellent tool for the treatment of these patients in
specific conditions. Objective: Describe the demographic and clinical characteristics of patients and the final
outcomes in patients with positive ANCAS vasculitis that required therapeutic plasma exchange (TPE).
Materials and methods: All patients under 18 years old with positive ANCAS vascultiis that required
TPE where included during the period of May 2010 and December 2013.
Results: 13 patients where treated, with a total of 73 TPE sessions. The average age was 52,3 years (Range
17 to 70). The principal diagnosis for interventions was rapidly progressive glomerulonephritis (RPGN)
plus alveolar hemorrhage (63%). The average number of sessions per patient was 5,6 (range 1 a 10) with an
average of plasma volume exchange per session of 1,26 (range 0.72 a 1,56). Of the 13 patients, 11 (84,6%)
required renal replacement therapy (RRT) during hospitalization. At discharge, 36.3% recover the renal
function, 27% continue on RRT and 36,3% died. There was at least one complication in 6,8% of all sessions.
Conclusions: TPE is an excellent tool to treat patients with positive ANCAS vasculitis that present with
RPGN, high levels of serum creatinine or dialysis need, or alveolar hemorrhage. This is a safe procedure
with comparable results according to International literature.Key words: Apheresis, plasmapheresis, therapeutic
plasma exchange, vasculitis, ANCA. |
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| ISSN: | 2389-7708 2500-5006 |