Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia
Introduction: The vasculitis ANCAS positive, are a group of diseases with different clinical manifestations. Therapeutic plasma exchange has become an excellent tool for the treatment of these patients in specific conditions. Objective: Describe the demographic and clinical characteristics of pati...
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| Format: | Article |
| Language: | English |
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Asociación Colombiana de Nefrología e Hipertensión Arterial
2014-05-01
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| Series: | Revista Colombiana de Nefrología |
| Subjects: | |
| Online Access: | http://www.revistanefrologia.org/index.php/rcn/article/view/167/pdf |
| _version_ | 1828871252272480256 |
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| author | Juan P. Córdoba Kateir Contreras Maite Hurtado Jessica Pinto Martha P. Rodríguez1 Carolina Larrarte |
| author_facet | Juan P. Córdoba Kateir Contreras Maite Hurtado Jessica Pinto Martha P. Rodríguez1 Carolina Larrarte |
| author_sort | Juan P. Córdoba |
| collection | DOAJ |
| description | Introduction: The vasculitis ANCAS positive, are a group of diseases with different clinical manifestations.
Therapeutic plasma exchange has become an excellent tool for the treatment of these patients in
specific conditions. Objective: Describe the demographic and clinical characteristics of patients and the final
outcomes in patients with positive ANCAS vasculitis that required therapeutic plasma exchange (TPE).
Materials and methods: All patients under 18 years old with positive ANCAS vascultiis that required
TPE where included during the period of May 2010 and December 2013.
Results: 13 patients where treated, with a total of 73 TPE sessions. The average age was 52,3 years (Range
17 to 70). The principal diagnosis for interventions was rapidly progressive glomerulonephritis (RPGN)
plus alveolar hemorrhage (63%). The average number of sessions per patient was 5,6 (range 1 a 10) with an
average of plasma volume exchange per session of 1,26 (range 0.72 a 1,56). Of the 13 patients, 11 (84,6%)
required renal replacement therapy (RRT) during hospitalization. At discharge, 36.3% recover the renal
function, 27% continue on RRT and 36,3% died. There was at least one complication in 6,8% of all sessions.
Conclusions: TPE is an excellent tool to treat patients with positive ANCAS vasculitis that present with
RPGN, high levels of serum creatinine or dialysis need, or alveolar hemorrhage. This is a safe procedure
with comparable results according to International literature.Key words: Apheresis, plasmapheresis, therapeutic
plasma exchange, vasculitis, ANCA. |
| first_indexed | 2024-12-13T06:29:14Z |
| format | Article |
| id | doaj.art-3ecf3334c8574b93aa3859f2b4ae66e9 |
| institution | Directory Open Access Journal |
| issn | 2389-7708 2500-5006 |
| language | English |
| last_indexed | 2024-12-13T06:29:14Z |
| publishDate | 2014-05-01 |
| publisher | Asociación Colombiana de Nefrología e Hipertensión Arterial |
| record_format | Article |
| series | Revista Colombiana de Nefrología |
| spelling | doaj.art-3ecf3334c8574b93aa3859f2b4ae66e92022-12-21T23:56:40ZengAsociación Colombiana de Nefrología e Hipertensión ArterialRevista Colombiana de Nefrología2389-77082500-50062014-05-01113910.22265/acnef.1.1.167Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, ColombiaJuan P. Córdoba0Kateir Contreras1Maite Hurtado2Jessica Pinto3Martha P. Rodríguez14Carolina Larrarte5Unidad de Nefrología, Hospital Universitario San Ignacio, Bogotá, ColombiaUnidad de Nefrología, Hospital Universitario San Ignacio, Bogotá, ColombiaUnidad de Nefrología, Hospital Universitario San Ignacio, Bogotá, ColombiaUnidad de Nefrología, Hospital Universitario San Ignacio, Bogotá, ColombiaUnidad de Nefrología, Hospital Universitario San Ignacio, Bogotá, ColombiaUnidad Renal, RTS - Agencia Santa Clara, Bogotá, ColombiaIntroduction: The vasculitis ANCAS positive, are a group of diseases with different clinical manifestations. Therapeutic plasma exchange has become an excellent tool for the treatment of these patients in specific conditions. Objective: Describe the demographic and clinical characteristics of patients and the final outcomes in patients with positive ANCAS vasculitis that required therapeutic plasma exchange (TPE). Materials and methods: All patients under 18 years old with positive ANCAS vascultiis that required TPE where included during the period of May 2010 and December 2013. Results: 13 patients where treated, with a total of 73 TPE sessions. The average age was 52,3 years (Range 17 to 70). The principal diagnosis for interventions was rapidly progressive glomerulonephritis (RPGN) plus alveolar hemorrhage (63%). The average number of sessions per patient was 5,6 (range 1 a 10) with an average of plasma volume exchange per session of 1,26 (range 0.72 a 1,56). Of the 13 patients, 11 (84,6%) required renal replacement therapy (RRT) during hospitalization. At discharge, 36.3% recover the renal function, 27% continue on RRT and 36,3% died. There was at least one complication in 6,8% of all sessions. Conclusions: TPE is an excellent tool to treat patients with positive ANCAS vasculitis that present with RPGN, high levels of serum creatinine or dialysis need, or alveolar hemorrhage. This is a safe procedure with comparable results according to International literature.Key words: Apheresis, plasmapheresis, therapeutic plasma exchange, vasculitis, ANCA.http://www.revistanefrologia.org/index.php/rcn/article/view/167/pdfApheresisplasmapheresistherapeutic plasma exchangevasculitis |
| spellingShingle | Juan P. Córdoba Kateir Contreras Maite Hurtado Jessica Pinto Martha P. Rodríguez1 Carolina Larrarte Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia Revista Colombiana de Nefrología Apheresis plasmapheresis therapeutic plasma exchange vasculitis |
| title | Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia |
| title_full | Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia |
| title_fullStr | Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia |
| title_full_unstemmed | Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia |
| title_short | Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia |
| title_sort | therapeutic plasma exchange in patients with pauciimmune vasculitis hospital universitario san ignacio experience bogota colombia |
| topic | Apheresis plasmapheresis therapeutic plasma exchange vasculitis |
| url | http://www.revistanefrologia.org/index.php/rcn/article/view/167/pdf |
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