Mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with age‐related hearing loss
Previous studies have revealed that age‐related hearing loss (AHL) in Cdk5 regulatory subunit‐associated protein 1 (Cdk5rap1)‐knockout mice is associated with pathology in the cochlea. Here, we aimed to identify mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with AHL. Mitochondri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13655 |
| _version_ | 1797789134841970688 |
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| author | Toru Miwa Tatsuya Katsuno Fan‐Yan Wei Kazuhito Tomizawa |
| author_facet | Toru Miwa Tatsuya Katsuno Fan‐Yan Wei Kazuhito Tomizawa |
| author_sort | Toru Miwa |
| collection | DOAJ |
| description | Previous studies have revealed that age‐related hearing loss (AHL) in Cdk5 regulatory subunit‐associated protein 1 (Cdk5rap1)‐knockout mice is associated with pathology in the cochlea. Here, we aimed to identify mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with AHL. Mitochondria in the spiral ganglion neurons (SGNs) and hair cells (HCs) were normal despite senescence; however, the mitochondria of types I, II, and IV spiral ligament fibrocytes were ballooned, damaged, and ballooned, respectively, in the stria vascularis. Our results suggest that the accumulation of dysfunctional mitochondria in the lateral wall, rather than the loss of HCs and SGNs, leads to the onset of AHL. Our results provide valuable information regarding the underlying mechanisms of AHL and the relationship between aberrant tRNA modification‐induced hearing loss and mitochondrial dysfunction. |
| first_indexed | 2024-03-13T01:46:26Z |
| format | Article |
| id | doaj.art-3ed5431d3e4944b88ffb410a89c82966 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-03-13T01:46:26Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-3ed5431d3e4944b88ffb410a89c829662023-07-03T07:24:35ZengWileyFEBS Open Bio2211-54632023-07-011371365137410.1002/2211-5463.13655Mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with age‐related hearing lossToru Miwa0Tatsuya Katsuno1Fan‐Yan Wei2Kazuhito Tomizawa3Department of Otolaryngology‐Head and Neck Surgery, Graduate School of Medicine Kyoto University JapanDepartment of Otolaryngology‐Head and Neck Surgery Osaka Metropolitan University JapanDepartment of Molecular Physiology, Faculty of Life Sciences Kumamoto University JapanDepartment of Molecular Physiology, Faculty of Life Sciences Kumamoto University JapanPrevious studies have revealed that age‐related hearing loss (AHL) in Cdk5 regulatory subunit‐associated protein 1 (Cdk5rap1)‐knockout mice is associated with pathology in the cochlea. Here, we aimed to identify mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with AHL. Mitochondria in the spiral ganglion neurons (SGNs) and hair cells (HCs) were normal despite senescence; however, the mitochondria of types I, II, and IV spiral ligament fibrocytes were ballooned, damaged, and ballooned, respectively, in the stria vascularis. Our results suggest that the accumulation of dysfunctional mitochondria in the lateral wall, rather than the loss of HCs and SGNs, leads to the onset of AHL. Our results provide valuable information regarding the underlying mechanisms of AHL and the relationship between aberrant tRNA modification‐induced hearing loss and mitochondrial dysfunction.https://doi.org/10.1002/2211-5463.13655age‐related hearing lossCdk5rap1microstructural findingsmitochondriamitochondrial tRNAtransmission electron microscopy |
| spellingShingle | Toru Miwa Tatsuya Katsuno Fan‐Yan Wei Kazuhito Tomizawa Mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with age‐related hearing loss FEBS Open Bio age‐related hearing loss Cdk5rap1 microstructural findings mitochondria mitochondrial tRNA transmission electron microscopy |
| title | Mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with age‐related hearing loss |
| title_full | Mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with age‐related hearing loss |
| title_fullStr | Mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with age‐related hearing loss |
| title_full_unstemmed | Mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with age‐related hearing loss |
| title_short | Mitochondrial alterations in the cochlea of Cdk5rap1‐knockout mice with age‐related hearing loss |
| title_sort | mitochondrial alterations in the cochlea of cdk5rap1 knockout mice with age related hearing loss |
| topic | age‐related hearing loss Cdk5rap1 microstructural findings mitochondria mitochondrial tRNA transmission electron microscopy |
| url | https://doi.org/10.1002/2211-5463.13655 |
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