Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso)
ABSTRACT Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2020-10-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600664&tlng=en |
| _version_ | 1798014533948669952 |
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| author | Miguel Madeira André Caroli Rocha Carolina Aguiar Moreira Águida Maria Menezes Aguiar Sergio Setsuo Maeda Abel Silveira Cardoso Charlles Heldan de Moura Castro Catarina Brasil D'Alva Barbara Campolina Carvalho Silva Bruno Ferraz-de-Souza Marise Lazaretti-Castro Francisco Bandeira Sandra R. Torres |
| author_facet | Miguel Madeira André Caroli Rocha Carolina Aguiar Moreira Águida Maria Menezes Aguiar Sergio Setsuo Maeda Abel Silveira Cardoso Charlles Heldan de Moura Castro Catarina Brasil D'Alva Barbara Campolina Carvalho Silva Bruno Ferraz-de-Souza Marise Lazaretti-Castro Francisco Bandeira Sandra R. Torres |
| author_sort | Miguel Madeira |
| collection | DOAJ |
| description | ABSTRACT Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The aim of this study was to discuss the risk factors for the development of MRONJ and prevention of this complication in patients with osteoporosis taking antiresorptive drugs and requiring invasive dental treatment. For this goal, a task force with representatives from three professional associations was appointed to review the pertinent literature and discuss systemic and local risk factors, prevention of MRONJ in patients with osteoporosis, and management of established MRONJ. Although scarce evidence links the use of antiresorptive agents in the context of osteoporosis to the development of MRONJ, these agents are considered a risk factor for this complication. Despite the rare reports of MRONJ in patients with osteoporosis, the severity of symptoms and impact of MRONJ in the patients' quality of life make it imperative for health care professionals to consider this complication when planning invasive dental procedures. |
| first_indexed | 2024-04-11T15:19:03Z |
| format | Article |
| id | doaj.art-3ed6523529f24046934e63e562dbb6c0 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-11T15:19:03Z |
| publishDate | 2020-10-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-3ed6523529f24046934e63e562dbb6c02022-12-22T04:16:24ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922020-10-0164666467210.20945/2359-3997000000301Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso)Miguel Madeirahttps://orcid.org/0000-0001-6752-2880André Caroli Rochahttps://orcid.org/0000-0003-0070-0640Carolina Aguiar Moreirahttps://orcid.org/0000-0002-9908-4907Águida Maria Menezes Aguiarhttps://orcid.org/0000-0002-9666-9272Sergio Setsuo Maedahttps://orcid.org/0000-0002-2669-4245Abel Silveira Cardosohttps://orcid.org/0000-0001-9771-3960Charlles Heldan de Moura Castrohttps://orcid.org/0000-0001-9144-996XCatarina Brasil D'Alvahttps://orcid.org/0000-0001-7332-9841Barbara Campolina Carvalho Silvahttps://orcid.org/0000-0001-7276-581XBruno Ferraz-de-Souzahttps://orcid.org/0000-0003-4863-2544Marise Lazaretti-Castrohttps://orcid.org/0000-0001-9186-2834Francisco Bandeirahttps://orcid.org/0000-0003-0290-0742Sandra R. Torreshttps://orcid.org/0000-0002-9271-3707ABSTRACT Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The aim of this study was to discuss the risk factors for the development of MRONJ and prevention of this complication in patients with osteoporosis taking antiresorptive drugs and requiring invasive dental treatment. For this goal, a task force with representatives from three professional associations was appointed to review the pertinent literature and discuss systemic and local risk factors, prevention of MRONJ in patients with osteoporosis, and management of established MRONJ. Although scarce evidence links the use of antiresorptive agents in the context of osteoporosis to the development of MRONJ, these agents are considered a risk factor for this complication. Despite the rare reports of MRONJ in patients with osteoporosis, the severity of symptoms and impact of MRONJ in the patients' quality of life make it imperative for health care professionals to consider this complication when planning invasive dental procedures.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600664&tlng=enOsteoporosisbisphosphonatemedication-related osteonecrosis of the jawantifracture therapydental care |
| spellingShingle | Miguel Madeira André Caroli Rocha Carolina Aguiar Moreira Águida Maria Menezes Aguiar Sergio Setsuo Maeda Abel Silveira Cardoso Charlles Heldan de Moura Castro Catarina Brasil D'Alva Barbara Campolina Carvalho Silva Bruno Ferraz-de-Souza Marise Lazaretti-Castro Francisco Bandeira Sandra R. Torres Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso) Archives of Endocrinology and Metabolism Osteoporosis bisphosphonate medication-related osteonecrosis of the jaw antifracture therapy dental care |
| title | Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso) |
| title_full | Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso) |
| title_fullStr | Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso) |
| title_full_unstemmed | Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso) |
| title_short | Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis – A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso) |
| title_sort | prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis a position paper of the brazilian society of endocrinology and metabolism sbem brazilian society of stomatology and oral pathology sobep and brazilian association for bone evaluation and osteometabolism abrasso |
| topic | Osteoporosis bisphosphonate medication-related osteonecrosis of the jaw antifracture therapy dental care |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600664&tlng=en |
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