Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study
OBJECTIVE: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. METHODS: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600006&lng=en&tlng=en |
| _version_ | 1819009085164486656 |
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| author | Maria José Penna Maisonnette de Attayde Silva Gilzandra Lira Dantas Florêncio José Roberto Erbolato Gabiatti Rose Luce do Amaral José Eleutério Júnior Ana Katherine da Silveira Gonçalves |
| author_facet | Maria José Penna Maisonnette de Attayde Silva Gilzandra Lira Dantas Florêncio José Roberto Erbolato Gabiatti Rose Luce do Amaral José Eleutério Júnior Ana Katherine da Silveira Gonçalves |
| author_sort | Maria José Penna Maisonnette de Attayde Silva |
| collection | DOAJ |
| description | OBJECTIVE: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. METHODS: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis. RESULTS: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively). CONCLUSION: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings. |
| first_indexed | 2024-12-21T00:50:45Z |
| format | Article |
| id | doaj.art-3ed660ab73e9405a8378caf13643261a |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-21T00:50:45Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-3ed660ab73e9405a8378caf13643261a2022-12-21T19:21:24ZengElsevierBrazilian Journal of Infectious Diseases1678-439115653353910.1590/S1413-86702011000600006S1413-86702011000600006Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis studyMaria José Penna Maisonnette de Attayde Silva0Gilzandra Lira Dantas Florêncio1José Roberto Erbolato Gabiatti2Rose Luce do Amaral3José Eleutério Júnior4Ana Katherine da Silveira Gonçalves5Universidade Federal do Rio Grande do NorteUniversidade Federal do Rio Grande do NorteUniversidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Federal do CearáUniversidade Federal do Rio Grande do NorteOBJECTIVE: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. METHODS: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis. RESULTS: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively). CONCLUSION: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600006&lng=en&tlng=enChlamydia trachomatisperinatal mortalitymorbiditymeta-analysis |
| spellingShingle | Maria José Penna Maisonnette de Attayde Silva Gilzandra Lira Dantas Florêncio José Roberto Erbolato Gabiatti Rose Luce do Amaral José Eleutério Júnior Ana Katherine da Silveira Gonçalves Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study Brazilian Journal of Infectious Diseases Chlamydia trachomatis perinatal mortality morbidity meta-analysis |
| title | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_full | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_fullStr | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_full_unstemmed | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_short | Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study |
| title_sort | perinatal morbidity and mortality associated with chlamydial infection a meta analysis study |
| topic | Chlamydia trachomatis perinatal mortality morbidity meta-analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600006&lng=en&tlng=en |
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