Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-04-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00615/full |
| _version_ | 1819289324298960896 |
|---|---|
| author | Dongshan Wan Dongshan Wan Wei Jiang Junwei Hao |
| author_facet | Dongshan Wan Dongshan Wan Wei Jiang Junwei Hao |
| author_sort | Dongshan Wan |
| collection | DOAJ |
| description | Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN) inflammatory signaling responses and other cellular processes such as autophagy, cell survival, senescence. cGAS-STING pathway interplays with other innate immune pathways, by which it participates in regulating infection, inflammatory disease, and cancer. The therapeutic approaches targeting this pathway show promise for future translation into clinical applications. Here, we present a review of the important previous works and recent advances regarding the cGAS-STING pathway, and provide a comprehensive understanding of the modulatory pattern of the cGAS-STING pathway under multifarious pathologic states. |
| first_indexed | 2024-12-24T03:05:02Z |
| format | Article |
| id | doaj.art-3eda01aa086d4226b055ee4c936f58f4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T03:05:02Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3eda01aa086d4226b055ee4c936f58f42022-12-21T17:18:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-04-011110.3389/fimmu.2020.00615523507Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory ResponseDongshan Wan0Dongshan Wan1Wei Jiang2Junwei Hao3Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDouble-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN) inflammatory signaling responses and other cellular processes such as autophagy, cell survival, senescence. cGAS-STING pathway interplays with other innate immune pathways, by which it participates in regulating infection, inflammatory disease, and cancer. The therapeutic approaches targeting this pathway show promise for future translation into clinical applications. Here, we present a review of the important previous works and recent advances regarding the cGAS-STING pathway, and provide a comprehensive understanding of the modulatory pattern of the cGAS-STING pathway under multifarious pathologic states.https://www.frontiersin.org/article/10.3389/fimmu.2020.00615/fullinflammationcGASSTINGcGAMPtype I interferonopathies |
| spellingShingle | Dongshan Wan Dongshan Wan Wei Jiang Junwei Hao Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response Frontiers in Immunology inflammation cGAS STING cGAMP type I interferonopathies |
| title | Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response |
| title_full | Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response |
| title_fullStr | Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response |
| title_full_unstemmed | Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response |
| title_short | Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response |
| title_sort | research advances in how the cgas sting pathway controls the cellular inflammatory response |
| topic | inflammation cGAS STING cGAMP type I interferonopathies |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00615/full |
| work_keys_str_mv | AT dongshanwan researchadvancesinhowthecgasstingpathwaycontrolsthecellularinflammatoryresponse AT dongshanwan researchadvancesinhowthecgasstingpathwaycontrolsthecellularinflammatoryresponse AT weijiang researchadvancesinhowthecgasstingpathwaycontrolsthecellularinflammatoryresponse AT junweihao researchadvancesinhowthecgasstingpathwaycontrolsthecellularinflammatoryresponse |