Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study
Objectives: Vascular hyperpermeability by loss of endothelial barrier integrity is a hallmark of sepsis. Vimentin is involved in the regulation of the endothelial function and inflammatory response. However, the serum level of vimentin and its clinical relevance in pediatric severe sepsis (PSS) rema...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122200279X |
| _version_ | 1828795247318007808 |
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| author | Huijie Miao Yun Cui Ye Lu Ting Sun Jiaying Dou Yuqian Ren Chunxia Wang Yucai Zhang |
| author_facet | Huijie Miao Yun Cui Ye Lu Ting Sun Jiaying Dou Yuqian Ren Chunxia Wang Yucai Zhang |
| author_sort | Huijie Miao |
| collection | DOAJ |
| description | Objectives: Vascular hyperpermeability by loss of endothelial barrier integrity is a hallmark of sepsis. Vimentin is involved in the regulation of the endothelial function and inflammatory response. However, the serum level of vimentin and its clinical relevance in pediatric severe sepsis (PSS) remain unknown. Methods: We conducted a prospective study of PSS cases who were admitted to the pediatric intensive care unit (PICU) from January 2018 to December 2020. Results: A total of 108 patients with PSS with a median age of 19.5 month were enrolled. The hospital mortality rate was 19.44% (21/108). Comparing with healthy controls, serum vimentin levels on PICU admission were significantly higher in patients with PSS (P < 0.001). The area under the ROC curve for vimentin to predict the hospital mortality was 0.712 (95% CI: 0.578–846) with a sensitivity of 71.43% and a specificity of 70.11%. Moreover, hospital mortality was significantly higher in patients with vimentin level over the cutoff value of 24.53 ng/ml than in patients with vimentin level below 24.53 ng/ml (P < 0.001). Conclusions: Serum vimentin level as an indicator of endothelial injury is associated with the prognosis of PSS, and serum vimentin level ≥24.53 ng/ml on PICU admission predicts high risk for hospital mortality in PSS. |
| first_indexed | 2024-12-12T04:00:37Z |
| format | Article |
| id | doaj.art-3eda71c6647847ffba0b6e47cdaac302 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T04:00:37Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-3eda71c6647847ffba0b6e47cdaac3022022-12-22T00:39:04ZengElsevierInternational Journal of Infectious Diseases1201-97122022-08-01121141147Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational studyHuijie Miao0Yun Cui1Ye Lu2Ting Sun3Jiaying Dou4Yuqian Ren5Chunxia Wang6Yucai Zhang7Department of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, Shanghai, China; Institute of Pediatric Infection, Immunity and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Clinical Research Unit, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Chunxia Wang, PhD, Department of Critical Care Medicine, Shanghai Children's Hospital, No. 355, Luding Road, Putuo District, Shanghai, 200062, China.Department of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Pediatric Critical Care, Shanghai Jiao Tong University, Shanghai, China; Institute of Pediatric Infection, Immunity and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: Yucai Zhang, MD, PhD, Department of Critical Care Medicine, Shanghai Children's Hospital, No. 355, Luding Road, Putuo District, Shanghai, 200062, China.Objectives: Vascular hyperpermeability by loss of endothelial barrier integrity is a hallmark of sepsis. Vimentin is involved in the regulation of the endothelial function and inflammatory response. However, the serum level of vimentin and its clinical relevance in pediatric severe sepsis (PSS) remain unknown. Methods: We conducted a prospective study of PSS cases who were admitted to the pediatric intensive care unit (PICU) from January 2018 to December 2020. Results: A total of 108 patients with PSS with a median age of 19.5 month were enrolled. The hospital mortality rate was 19.44% (21/108). Comparing with healthy controls, serum vimentin levels on PICU admission were significantly higher in patients with PSS (P < 0.001). The area under the ROC curve for vimentin to predict the hospital mortality was 0.712 (95% CI: 0.578–846) with a sensitivity of 71.43% and a specificity of 70.11%. Moreover, hospital mortality was significantly higher in patients with vimentin level over the cutoff value of 24.53 ng/ml than in patients with vimentin level below 24.53 ng/ml (P < 0.001). Conclusions: Serum vimentin level as an indicator of endothelial injury is associated with the prognosis of PSS, and serum vimentin level ≥24.53 ng/ml on PICU admission predicts high risk for hospital mortality in PSS.http://www.sciencedirect.com/science/article/pii/S120197122200279XVimentinHospital mortalityEndothelial injurySevere sepsisChildren |
| spellingShingle | Huijie Miao Yun Cui Ye Lu Ting Sun Jiaying Dou Yuqian Ren Chunxia Wang Yucai Zhang Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study International Journal of Infectious Diseases Vimentin Hospital mortality Endothelial injury Severe sepsis Children |
| title | Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study |
| title_full | Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study |
| title_fullStr | Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study |
| title_full_unstemmed | Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study |
| title_short | Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study |
| title_sort | serum vimentin predicts mortality in pediatric severe sepsis a prospective observational study |
| topic | Vimentin Hospital mortality Endothelial injury Severe sepsis Children |
| url | http://www.sciencedirect.com/science/article/pii/S120197122200279X |
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