From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation
PROTAC is a rapidly developing engineering technology for targeted protein degradation using the ubiquitin–proteasome system, which has promising applications for inflammatory diseases, neurodegenerative diseases, and malignant tumors. This paper gives a brief overview of the development and design...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/17/1/100 |
| _version_ | 1827371296102547456 |
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| author | Siqi Wang Fuchu He Chunyan Tian Aihua Sun |
| author_facet | Siqi Wang Fuchu He Chunyan Tian Aihua Sun |
| author_sort | Siqi Wang |
| collection | DOAJ |
| description | PROTAC is a rapidly developing engineering technology for targeted protein degradation using the ubiquitin–proteasome system, which has promising applications for inflammatory diseases, neurodegenerative diseases, and malignant tumors. This paper gives a brief overview of the development and design principles of PROTAC, with a special focus on PROTAC-based explorations in recent years aimed at achieving controlled protein degradation and improving the bioavailability of PROTAC, as well as TPD technologies that use other pathways such as autophagy and lysosomes to achieve targeted protein degradation. |
| first_indexed | 2024-03-08T10:38:15Z |
| format | Article |
| id | doaj.art-3edbd4ee2d7c46f59e3c9fd5bf989155 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-08T10:38:15Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-3edbd4ee2d7c46f59e3c9fd5bf9891552024-01-26T18:06:03ZengMDPI AGPharmaceuticals1424-82472024-01-0117110010.3390/ph17010100From PROTAC to TPD: Advances and Opportunities in Targeted Protein DegradationSiqi Wang0Fuchu He1Chunyan Tian2Aihua Sun3State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, ChinaState Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, ChinaState Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, ChinaState Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, ChinaPROTAC is a rapidly developing engineering technology for targeted protein degradation using the ubiquitin–proteasome system, which has promising applications for inflammatory diseases, neurodegenerative diseases, and malignant tumors. This paper gives a brief overview of the development and design principles of PROTAC, with a special focus on PROTAC-based explorations in recent years aimed at achieving controlled protein degradation and improving the bioavailability of PROTAC, as well as TPD technologies that use other pathways such as autophagy and lysosomes to achieve targeted protein degradation.https://www.mdpi.com/1424-8247/17/1/100PROTACTPDtargeted protein degradationprotein-hydrolysis-targeted chimerasubiquitin–proteasome system |
| spellingShingle | Siqi Wang Fuchu He Chunyan Tian Aihua Sun From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation Pharmaceuticals PROTAC TPD targeted protein degradation protein-hydrolysis-targeted chimeras ubiquitin–proteasome system |
| title | From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation |
| title_full | From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation |
| title_fullStr | From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation |
| title_full_unstemmed | From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation |
| title_short | From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation |
| title_sort | from protac to tpd advances and opportunities in targeted protein degradation |
| topic | PROTAC TPD targeted protein degradation protein-hydrolysis-targeted chimeras ubiquitin–proteasome system |
| url | https://www.mdpi.com/1424-8247/17/1/100 |
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