From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation

From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation

PROTAC is a rapidly developing engineering technology for targeted protein degradation using the ubiquitin–proteasome system, which has promising applications for inflammatory diseases, neurodegenerative diseases, and malignant tumors. This paper gives a brief overview of the development and design...

Full description

Bibliographic Details
Main Authors:	Siqi Wang, Fuchu He, Chunyan Tian, Aihua Sun
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	Pharmaceuticals
Subjects:	PROTAC TPD targeted protein degradation protein-hydrolysis-targeted chimeras ubiquitin–proteasome system
Online Access:	https://www.mdpi.com/1424-8247/17/1/100

Similar Items

The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents
by: Bernat Coll-Martínez, et al.
Published: (2020-12-01)

From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
by: Carlotta Cecchini, et al.
Published: (2021-04-01)

mRNA PROTACs: engineering PROTACs for high‐efficiency targeted protein degradation
by: Xiaoqi Xue, et al.
Published: (2024-02-01)

Proteolysis-targeting chimeras (PROTACs) in cancer therapy
by: Xinyi Li, et al.
Published: (2022-04-01)

Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)
by: Huifang Wang, et al.
Published: (2023-07-01)

Proteolysis targeting chimeras (PROTACs) in cancer therapy
by: Alberto Ocaña, et al.
Published: (2020-09-01)

Breaking Bad Proteins—Discovery Approaches and the Road to Clinic for Degraders
by: Corentin Bouvier, et al.
Published: (2024-03-01)

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs
by: Mikihiko Naito, et al.
Published: (2019-12-01)

Targeted Protein Degradation: Principles and Applications of the Proteasome
by: Yosup Kim, et al.
Published: (2023-07-01)

Linkers as Game-changers in PROTAC Technology: Emphasizing General Trends in PROTAC Pharmacokinetics for their Rational Design
by: Carlotta Cecchini, et al.
Published: (2022-04-01)

PROTAC technology for the treatment of Alzheimer’s disease: advances and perspectives
by: Hiroyuki Inuzuka, et al.
Published: (2022-01-01)

An overview of PROTACs: a promising drug discovery paradigm
by: Zi Liu, et al.
Published: (2022-12-01)

Recent Advances in PROTACs for Drug Targeted Protein Research
by: Tingting Yao, et al.
Published: (2022-09-01)

PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
by: Si-Min Qi, et al.
Published: (2021-05-01)

Targeted Protein Degradation Systems: Controlling Protein Stability Using E3 Ubiquitin Ligases in Eukaryotic Species
by: Yoshitaka Ogawa, et al.
Published: (2024-01-01)

Cancer-Specific Delivery of Proteolysis-Targeting Chimeras (PROTACs) and Their Application to Cancer Immunotherapy
by: Yujeong Moon, et al.
Published: (2023-01-01)

Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1
by: Mingxing Hu, et al.
Published: (2020-10-01)

A Mechanistic Pharmacodynamic Modeling Framework for the Assessment and Optimization of Proteolysis Targeting Chimeras (PROTACs)
by: Robin Thomas Ulrich Haid, et al.
Published: (2023-01-01)

Recent Advances in PROTAC-Based Antiviral Strategies
by: Haleema Ahmad, et al.
Published: (2023-01-01)

Proteolysis-Targeting Chimeras (PROTACs) in Cancer Therapy: Present and Future
by: Rui Li, et al.
Published: (2022-12-01)

Recent Advances in Optically Controlled PROTAC
by: Muzi Ouyang, et al.
Published: (2023-11-01)

Recent Advances of Degradation Technologies Based on PROTAC Mechanism
by: Mingchao Xiao, et al.
Published: (2022-09-01)

Proteolysis-targeting chimaeras (PROTACs) as pharmacological tools and therapeutic agents: advances and future challenges
by: Chao Wang, et al.
Published: (2022-12-01)

PROTAC-Based Protein Degradation as a Promising Strategy for Targeted Therapy in Sarcomas
by: Caterina Mancarella, et al.
Published: (2023-11-01)

Development of Agonist-Based PROTACs Targeting Liver X Receptor
by: Hanqiao Xu, et al.
Published: (2021-05-01)

Small-Molecule Inhibitors and Degraders Targeting KRAS-Driven Cancers
by: Soonsil Hyun, et al.
Published: (2021-11-01)

Editorial: Application of PROTACs as a Novel Strategy for Drug Discovery
by: Hany S. Ibrahim, et al.
Published: (2021-07-01)

Major Advances in Emerging Degrader Technologies
by: Hang Luo, et al.
Published: (2022-06-01)

Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation
by: Ming He, et al.
Published: (2021-06-01)

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope
by: Sinan Ma, et al.
Published: (2022-07-01)

Editorial: PROTACs: Targeted therapies for cancer treatment
by: Sobia Tabassum
Published: (2023-02-01)

PROTAC vaccine: A new way to live attenuated vaccines
by: Zhen Li, et al.
Published: (2022-10-01)

Central Nervous System Targeted Protein Degraders
by: Bedwyr ab Ion Thomas, et al.
Published: (2023-07-01)

Overcoming Cancer Drug Resistance Utilizing PROTAC Technology
by: Matthew R. Burke, et al.
Published: (2022-04-01)

MDM2-Based Proteolysis-Targeting Chimeras (PROTACs): An Innovative Drug Strategy for Cancer Treatment
by: André T. S. Vicente, et al.
Published: (2022-09-01)

Emerging Strategies in Proteolysis-Targeting Chimeras (PROTACs): Highlights from 2022
by: Rekha Tamatam, et al.
Published: (2023-03-01)

PROTACs targeting epigenetic proteins
by: Chao Zhang, et al.
Published: (2023-12-01)

News from DMCCB – Targeted Protein Degradation
by: Georg Jaeschke
Published: (2018-12-01)

Design, Synthesis and Biological Evaluation of α-Synuclein Proteolysis-Targeting Chimeras
by: Tianzhi Wen, et al.
Published: (2023-05-01)

Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors
by: Gabriel LaPlante, et al.
Published: (2021-06-01)