Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling

Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling

Summary: Background: Homeodomain-Interacting Protein Kinase 2 (HIPK2) has been reported to maintain basal cardiac function, however, its role in pathological cardiac remodeling remains unclear. Methods: HIPK2 inhibitors (tBID and PKI1H) treated mice and two lines of HIPK2−/− mice were subjected to...

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Bibliographic Details
Main Authors: Qiulian Zhou, Danni Meng, Feng Li, Xiao Zhang, Li Liu, Yujiao Zhu, Shuqin Liu, Minjun Xu, Jiali Deng, Zhiyong Lei, Joost P.G. Sluijter, Junjie Xiao
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:EBioMedicine
Subjects:
Pathological cardiac remodeling
HIPK2
CLEC4D
EGR3
Smad3
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642200456X

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