Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors
Multidrug-resistant Gram-negative bacteria such as <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and members of the Enterobacterales order are a challenging multi-sectorial and global threat, being listed by the WHO in the priority list of pathogens requiring...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/9/7892 |
| _version_ | 1797602508893323264 |
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| author | Ilda Czobor Barbu Irina Gheorghe-Barbu Georgiana Alexandra Grigore Corneliu Ovidiu Vrancianu Mariana Carmen Chifiriuc |
| author_facet | Ilda Czobor Barbu Irina Gheorghe-Barbu Georgiana Alexandra Grigore Corneliu Ovidiu Vrancianu Mariana Carmen Chifiriuc |
| author_sort | Ilda Czobor Barbu |
| collection | DOAJ |
| description | Multidrug-resistant Gram-negative bacteria such as <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and members of the Enterobacterales order are a challenging multi-sectorial and global threat, being listed by the WHO in the priority list of pathogens requiring the urgent discovery and development of therapeutic strategies. We present here an overview of the antibiotic resistance profiles and epidemiology of Gram-negative pathogens listed in the ESCAPE group circulating in Romania. The review starts with a discussion of the mechanisms and clinical significance of Gram-negative bacteria, the most frequent genetic determinants of resistance, and then summarizes and discusses the epidemiological studies reported for <i>A. baumannii</i>, <i>P. aeruginosa</i>, and Enterobacterales-resistant strains circulating in Romania, both in hospital and veterinary settings and mirrored in the aquatic environment. The Romanian landscape of Gram-negative pathogens included in the ESCAPE list reveals that all significant, clinically relevant, globally spread antibiotic resistance genes and carrying platforms are well established in different geographical areas of Romania and have already been disseminated beyond clinical settings. |
| first_indexed | 2024-03-11T04:16:59Z |
| format | Article |
| id | doaj.art-3edd25ae407d4164ada09c5b75781a7e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:16:59Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3edd25ae407d4164ada09c5b75781a7e2023-11-17T23:02:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01249789210.3390/ijms24097892Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic SectorsIlda Czobor Barbu0Irina Gheorghe-Barbu1Georgiana Alexandra Grigore2Corneliu Ovidiu Vrancianu3Mariana Carmen Chifiriuc4Microbiology-Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMicrobiology-Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMicrobiology-Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMicrobiology-Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMicrobiology-Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMultidrug-resistant Gram-negative bacteria such as <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, and members of the Enterobacterales order are a challenging multi-sectorial and global threat, being listed by the WHO in the priority list of pathogens requiring the urgent discovery and development of therapeutic strategies. We present here an overview of the antibiotic resistance profiles and epidemiology of Gram-negative pathogens listed in the ESCAPE group circulating in Romania. The review starts with a discussion of the mechanisms and clinical significance of Gram-negative bacteria, the most frequent genetic determinants of resistance, and then summarizes and discusses the epidemiological studies reported for <i>A. baumannii</i>, <i>P. aeruginosa</i>, and Enterobacterales-resistant strains circulating in Romania, both in hospital and veterinary settings and mirrored in the aquatic environment. The Romanian landscape of Gram-negative pathogens included in the ESCAPE list reveals that all significant, clinically relevant, globally spread antibiotic resistance genes and carrying platforms are well established in different geographical areas of Romania and have already been disseminated beyond clinical settings.https://www.mdpi.com/1422-0067/24/9/7892Gram-negative ESCAPE pathogensresistanceintra-hospital infectionscommunity-acquiredaquatic resistome |
| spellingShingle | Ilda Czobor Barbu Irina Gheorghe-Barbu Georgiana Alexandra Grigore Corneliu Ovidiu Vrancianu Mariana Carmen Chifiriuc Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors International Journal of Molecular Sciences Gram-negative ESCAPE pathogens resistance intra-hospital infections community-acquired aquatic resistome |
| title | Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors |
| title_full | Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors |
| title_fullStr | Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors |
| title_full_unstemmed | Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors |
| title_short | Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors |
| title_sort | antimicrobial resistance in romania updates on gram negative escape pathogens in the clinical veterinary and aquatic sectors |
| topic | Gram-negative ESCAPE pathogens resistance intra-hospital infections community-acquired aquatic resistome |
| url | https://www.mdpi.com/1422-0067/24/9/7892 |
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