Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression
GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08337-4 |
| _version_ | 1818405315624828928 |
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| author | Ying Jin Genevieve H. L. Roberts Tracey M. Ferrara Songtao Ben Nanja van Geel Albert Wolkerstorfer Khaled Ezzedine Janet Siebert Charles P. Neff Brent E. Palmer Stephanie A. Santorico Richard A. Spritz |
| author_facet | Ying Jin Genevieve H. L. Roberts Tracey M. Ferrara Songtao Ben Nanja van Geel Albert Wolkerstorfer Khaled Ezzedine Janet Siebert Charles P. Neff Brent E. Palmer Stephanie A. Santorico Richard A. Spritz |
| author_sort | Ying Jin |
| collection | DOAJ |
| description | GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region. |
| first_indexed | 2024-12-14T08:54:06Z |
| format | Article |
| id | doaj.art-3edf3eefa11e40429926cb0f0aa5c365 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:54:06Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3edf3eefa11e40429926cb0f0aa5c3652022-12-21T23:08:58ZengNature PortfolioNature Communications2041-17232019-01-0110111010.1038/s41467-019-08337-4Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expressionYing Jin0Genevieve H. L. Roberts1Tracey M. Ferrara2Songtao Ben3Nanja van Geel4Albert Wolkerstorfer5Khaled Ezzedine6Janet Siebert7Charles P. Neff8Brent E. Palmer9Stephanie A. Santorico10Richard A. Spritz11Human Medical Genetics and Genomics Program, University of Colorado School of MedicineHuman Medical Genetics and Genomics Program, University of Colorado School of MedicineHuman Medical Genetics and Genomics Program, University of Colorado School of MedicineHuman Medical Genetics and Genomics Program, University of Colorado School of MedicineDepartment of Dermatology, Ghent University HospitalNetherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Centre University of AmsterdamDepartment of Dermatology, Hôpital Henri Mondor, Université Paris-Est CréteilCytoAnalyticsDepartment of Medicine, University of Colorado School of MedicineDepartment of Medicine, University of Colorado School of MedicineHuman Medical Genetics and Genomics Program, University of Colorado School of MedicineHuman Medical Genetics and Genomics Program, University of Colorado School of MedicineGWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.https://doi.org/10.1038/s41467-019-08337-4 |
| spellingShingle | Ying Jin Genevieve H. L. Roberts Tracey M. Ferrara Songtao Ben Nanja van Geel Albert Wolkerstorfer Khaled Ezzedine Janet Siebert Charles P. Neff Brent E. Palmer Stephanie A. Santorico Richard A. Spritz Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression Nature Communications |
| title | Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression |
| title_full | Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression |
| title_fullStr | Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression |
| title_full_unstemmed | Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression |
| title_short | Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression |
| title_sort | early onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class ii hla expression |
| url | https://doi.org/10.1038/s41467-019-08337-4 |
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