Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.

Bibliographic Details
Main Authors: Ying Jin, Genevieve H. L. Roberts, Tracey M. Ferrara, Songtao Ben, Nanja van Geel, Albert Wolkerstorfer, Khaled Ezzedine, Janet Siebert, Charles P. Neff, Brent E. Palmer, Stephanie A. Santorico, Richard A. Spritz
Format: Article
Language:English
Published: Nature Portfolio 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08337-4

Internet

https://doi.org/10.1038/s41467-019-08337-4

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