Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli

Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli

ABSTRACT Bacteria have to process several levels of gene regulation and coordination of interconnected regulatory networks to ensure the most adequate cellular response to specific growth conditions. Especially, expression of complex and costly fitness and pathogenicity-associated traits is coordina...

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Main Authors: Nadine Rehm, Alexander Wallenstein, Marla Keizers, Stefan Homburg, Giuseppe Magistro, Camille V. Chagneau, Hanna Klimek, Olga Revelles, Emmanuelle Helloin, Johannes Putze, Jean-Philippe Nougayrède, Sören Schubert, Eric Oswald, Ulrich Dobrindt
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
secondary metabolite
cytopathic effect
BarA-UvrY
two-component regulatory systems
pathogenicity islands
high pathogenicity island
Online Access:https://journals.asm.org/doi/10.1128/mbio.03814-21

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