Retinoids – A Perspective To Teratogenic Effects
<p>Since the role of retinoids in normal growth, reproduction, maintenance and differentiantion of epithelial tissue has been known, the therapeutic value of retinoids has been utilised in disorders resembling vitamin A (retinol) deficiency. Much effort has been directed to developing less tox...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Dentistry, Universitas Indonesia
2015-10-01
|
| Series: | Journal of Dentistry Indonesia |
| Online Access: | http://jdentistry.ui.ac.id/index.php/JDI/article/view/806 |
| _version_ | 1828399092937523200 |
|---|---|
| author | Elza Ibrahim Auerkari |
| author_facet | Elza Ibrahim Auerkari |
| author_sort | Elza Ibrahim Auerkari |
| collection | DOAJ |
| description | <p>Since the role of retinoids in normal growth, reproduction, maintenance and differentiantion of epithelial tissue has been known, the therapeutic value of retinoids has been utilised in disorders resembling vitamin A (retinol) deficiency. Much effort has been directed to developing less toxic retinoids to increase this therapeutic potential, and now more than 2000 synthetic retinoids are known. However, the most severe side effect of retinoids is their teratogenicity, and a desired goal in the retinoids development is in dissociating the therapeutic benefits from teratogenic risk. It is not known if this result can be achieved, but increasing the understanding of the basic molecular mechanisms of retinoic action should offer one route to the attainment of this goal. This work reviews of the molecular biology of retinoids with particular reference with teratogenic effects, and summarises the strategies for managing the teratogenic risk with oral retinoid therapy.</p> |
| first_indexed | 2024-12-10T09:11:26Z |
| format | Article |
| id | doaj.art-3ee1d365647e4de0b20ed5102cc49c7b |
| institution | Directory Open Access Journal |
| issn | 1693-9697 2355-4800 |
| language | English |
| last_indexed | 2024-12-10T09:11:26Z |
| publishDate | 2015-10-01 |
| publisher | Faculty of Dentistry, Universitas Indonesia |
| record_format | Article |
| series | Journal of Dentistry Indonesia |
| spelling | doaj.art-3ee1d365647e4de0b20ed5102cc49c7b2022-12-22T01:54:59ZengFaculty of Dentistry, Universitas IndonesiaJournal of Dentistry Indonesia1693-96972355-48002015-10-0161465110.14693/jdi.v6i1.806700Retinoids – A Perspective To Teratogenic EffectsElza Ibrahim Auerkari0Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430<p>Since the role of retinoids in normal growth, reproduction, maintenance and differentiantion of epithelial tissue has been known, the therapeutic value of retinoids has been utilised in disorders resembling vitamin A (retinol) deficiency. Much effort has been directed to developing less toxic retinoids to increase this therapeutic potential, and now more than 2000 synthetic retinoids are known. However, the most severe side effect of retinoids is their teratogenicity, and a desired goal in the retinoids development is in dissociating the therapeutic benefits from teratogenic risk. It is not known if this result can be achieved, but increasing the understanding of the basic molecular mechanisms of retinoic action should offer one route to the attainment of this goal. This work reviews of the molecular biology of retinoids with particular reference with teratogenic effects, and summarises the strategies for managing the teratogenic risk with oral retinoid therapy.</p>http://jdentistry.ui.ac.id/index.php/JDI/article/view/806 |
| spellingShingle | Elza Ibrahim Auerkari Retinoids – A Perspective To Teratogenic Effects Journal of Dentistry Indonesia |
| title | Retinoids – A Perspective To Teratogenic Effects |
| title_full | Retinoids – A Perspective To Teratogenic Effects |
| title_fullStr | Retinoids – A Perspective To Teratogenic Effects |
| title_full_unstemmed | Retinoids – A Perspective To Teratogenic Effects |
| title_short | Retinoids – A Perspective To Teratogenic Effects |
| title_sort | retinoids a perspective to teratogenic effects |
| url | http://jdentistry.ui.ac.id/index.php/JDI/article/view/806 |
| work_keys_str_mv | AT elzaibrahimauerkari retinoidsaperspectivetoteratogeniceffects |