Rapid sensitive validated UPLCâMS method for determination of venlafaxine and its metabolite in rat plasma: Application to pharmacokinetic study

A new ultra-performance liquid chromatographyâelectrospray ionization mass spectrometry (UPLCâMS/ESI) method for simultaneous determination of venlafaxine (VEN) and its metabolite O-desmethylvenlafaxine (ODV) in rat plasma has been developed and validated using Venlafaxine d6 as the internal standar...

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Hlavní autoři: Sunil Kumar Dubey, R.N. Saha, Hemanth Jangala, S. Pasha
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2013-12-01
Edice:Journal of Pharmaceutical Analysis
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2095177913000567