Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation

Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation

Summary: Histone chaperone FACT is commonly expressed and essential for the viability of transformed but not normal cells, and its expression levels correlate with poor prognosis in patients with cancer. FACT binds several components of nucleosomes and has been viewed as a factor destabilizing nucle...

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Bibliographic Details
Main Authors: Poorva Sandlesh, Alfiya Safina, Imon Goswami, Laura Prendergast, Spenser Rosario, Eduardo C. Gomez, Jianmin Wang, Katerina V. Gurova
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Biological Sciences
Molecular Biology
Chromosome Organization
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030362X

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