Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment
Cancers are the leading cause of death, causing around 10 million deaths annually by 2020. The most common cancers are those affecting the breast, lungs, colon, and rectum. However, it has been noted that cancer metastasis is more lethal than just cancer incidence and accounts for more than 90% of c...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/10/4/114 |
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| author | Sagorika Nag Abhimanyu Mandal Aryaman Joshi Neeraj Jain Ravi Shanker Srivastava Sanjay Singh Arun Khattri |
| author_facet | Sagorika Nag Abhimanyu Mandal Aryaman Joshi Neeraj Jain Ravi Shanker Srivastava Sanjay Singh Arun Khattri |
| author_sort | Sagorika Nag |
| collection | DOAJ |
| description | Cancers are the leading cause of death, causing around 10 million deaths annually by 2020. The most common cancers are those affecting the breast, lungs, colon, and rectum. However, it has been noted that cancer metastasis is more lethal than just cancer incidence and accounts for more than 90% of cancer deaths. Thus, early detection and prevention of cancer metastasis have the capability to save millions of lives. Finding novel biomarkers and targets for screening, determination of prognosis, targeted therapies, etc., are ways of doing so. In this review, we propose various sialyltransferases and neuraminidases as potential therapeutic targets for the treatment of the most common cancers, along with a few rare ones, on the basis of existing experimental and in silico data. This compilation of available cancer studies aiming at sialyltransferases and neuraminidases will serve as a guide for scientists and researchers working on possible targets for various cancers and will also provide data about the existing drugs which inhibit the action of these enzymes. |
| first_indexed | 2024-03-09T17:07:12Z |
| format | Article |
| id | doaj.art-3ee29aaf82b940c39158da5ec57ba93c |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-09T17:07:12Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-3ee29aaf82b940c39158da5ec57ba93c2023-11-24T14:21:46ZengMDPI AGDiseases2079-97212022-11-0110411410.3390/diseases10040114Sialyltransferases and Neuraminidases: Potential Targets for Cancer TreatmentSagorika Nag0Abhimanyu Mandal1Aryaman Joshi2Neeraj Jain3Ravi Shanker Srivastava4Sanjay Singh5Arun Khattri6Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, IndiaDepartment of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, IndiaDepartment of Chemical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, IndiaDivision of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaDepartment of Pharmacology, Career Institute of Medical Sciences & Hospital, Lucknow 226020, IndiaDepartment of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, IndiaDepartment of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, IndiaCancers are the leading cause of death, causing around 10 million deaths annually by 2020. The most common cancers are those affecting the breast, lungs, colon, and rectum. However, it has been noted that cancer metastasis is more lethal than just cancer incidence and accounts for more than 90% of cancer deaths. Thus, early detection and prevention of cancer metastasis have the capability to save millions of lives. Finding novel biomarkers and targets for screening, determination of prognosis, targeted therapies, etc., are ways of doing so. In this review, we propose various sialyltransferases and neuraminidases as potential therapeutic targets for the treatment of the most common cancers, along with a few rare ones, on the basis of existing experimental and in silico data. This compilation of available cancer studies aiming at sialyltransferases and neuraminidases will serve as a guide for scientists and researchers working on possible targets for various cancers and will also provide data about the existing drugs which inhibit the action of these enzymes.https://www.mdpi.com/2079-9721/10/4/114sialyltransferasesneuraminidasesovarian cancerbreast cancerpancreatic cancerchemoresistance |
| spellingShingle | Sagorika Nag Abhimanyu Mandal Aryaman Joshi Neeraj Jain Ravi Shanker Srivastava Sanjay Singh Arun Khattri Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment Diseases sialyltransferases neuraminidases ovarian cancer breast cancer pancreatic cancer chemoresistance |
| title | Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment |
| title_full | Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment |
| title_fullStr | Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment |
| title_full_unstemmed | Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment |
| title_short | Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment |
| title_sort | sialyltransferases and neuraminidases potential targets for cancer treatment |
| topic | sialyltransferases neuraminidases ovarian cancer breast cancer pancreatic cancer chemoresistance |
| url | https://www.mdpi.com/2079-9721/10/4/114 |
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