Combination of Enzymes with Materials to Give Them Antimicrobial Features: Modern Trends and Perspectives
Multidrug-resistant bacteria form serious problems in many areas, including medicine and the food industry. At the same time, great interest is shown in the transfer or enhancement of antimicrobial properties to various materials by modifying them with enzymes. The use of enzymes in biomaterials wit...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/14/2/64 |
| _version_ | 1797620111986655232 |
|---|---|
| author | Elena Efremenko Nikolay Stepanov Aysel Aslanli Ilya Lyagin Olga Senko Olga Maslova |
| author_facet | Elena Efremenko Nikolay Stepanov Aysel Aslanli Ilya Lyagin Olga Senko Olga Maslova |
| author_sort | Elena Efremenko |
| collection | DOAJ |
| description | Multidrug-resistant bacteria form serious problems in many areas, including medicine and the food industry. At the same time, great interest is shown in the transfer or enhancement of antimicrobial properties to various materials by modifying them with enzymes. The use of enzymes in biomaterials with antimicrobial properties is important because enzymes can be used as the main active components providing antimicrobial properties of functionalized composite biomaterials, or can serve as enhancers of the antimicrobial action of certain substances (antibiotics, antimicrobial peptides, metal nanoparticles, etc.) against cells of various microorganisms. Enzymes can simultaneously widen the spectrum of antimicrobial activity of biomaterials. This review presents the most promising enzymes recently used for the production of antibacterial materials, namely hydrolases and oxidoreductases. Computer modeling plays an important role in finding the most effective combinations between enzymes and antimicrobial compounds, revealing their possible interactions. The range of materials that can be functionalized using enzymes looks diverse. The physicochemical characteristics and functionalization methods of the materials have a significant impact on the activity of enzymes. In this context, fibrous materials are of particular interest. The purpose of this review is to analyze the current state of the art in this area. |
| first_indexed | 2024-03-11T08:37:02Z |
| format | Article |
| id | doaj.art-3ee5be8f679a4161807599d88c7929bc |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T08:37:02Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-3ee5be8f679a4161807599d88c7929bc2023-11-16T21:24:10ZengMDPI AGJournal of Functional Biomaterials2079-49832023-01-011426410.3390/jfb14020064Combination of Enzymes with Materials to Give Them Antimicrobial Features: Modern Trends and PerspectivesElena Efremenko0Nikolay Stepanov1Aysel Aslanli2Ilya Lyagin3Olga Senko4Olga Maslova5Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, RussiaMultidrug-resistant bacteria form serious problems in many areas, including medicine and the food industry. At the same time, great interest is shown in the transfer or enhancement of antimicrobial properties to various materials by modifying them with enzymes. The use of enzymes in biomaterials with antimicrobial properties is important because enzymes can be used as the main active components providing antimicrobial properties of functionalized composite biomaterials, or can serve as enhancers of the antimicrobial action of certain substances (antibiotics, antimicrobial peptides, metal nanoparticles, etc.) against cells of various microorganisms. Enzymes can simultaneously widen the spectrum of antimicrobial activity of biomaterials. This review presents the most promising enzymes recently used for the production of antibacterial materials, namely hydrolases and oxidoreductases. Computer modeling plays an important role in finding the most effective combinations between enzymes and antimicrobial compounds, revealing their possible interactions. The range of materials that can be functionalized using enzymes looks diverse. The physicochemical characteristics and functionalization methods of the materials have a significant impact on the activity of enzymes. In this context, fibrous materials are of particular interest. The purpose of this review is to analyze the current state of the art in this area.https://www.mdpi.com/2079-4983/14/2/64oxidoreductaseshydrolyseslactonasesantibioticsantimicrobial peptidesmetal nanoparticles |
| spellingShingle | Elena Efremenko Nikolay Stepanov Aysel Aslanli Ilya Lyagin Olga Senko Olga Maslova Combination of Enzymes with Materials to Give Them Antimicrobial Features: Modern Trends and Perspectives Journal of Functional Biomaterials oxidoreductases hydrolyses lactonases antibiotics antimicrobial peptides metal nanoparticles |
| title | Combination of Enzymes with Materials to Give Them Antimicrobial Features: Modern Trends and Perspectives |
| title_full | Combination of Enzymes with Materials to Give Them Antimicrobial Features: Modern Trends and Perspectives |
| title_fullStr | Combination of Enzymes with Materials to Give Them Antimicrobial Features: Modern Trends and Perspectives |
| title_full_unstemmed | Combination of Enzymes with Materials to Give Them Antimicrobial Features: Modern Trends and Perspectives |
| title_short | Combination of Enzymes with Materials to Give Them Antimicrobial Features: Modern Trends and Perspectives |
| title_sort | combination of enzymes with materials to give them antimicrobial features modern trends and perspectives |
| topic | oxidoreductases hydrolyses lactonases antibiotics antimicrobial peptides metal nanoparticles |
| url | https://www.mdpi.com/2079-4983/14/2/64 |
| work_keys_str_mv | AT elenaefremenko combinationofenzymeswithmaterialstogivethemantimicrobialfeaturesmoderntrendsandperspectives AT nikolaystepanov combinationofenzymeswithmaterialstogivethemantimicrobialfeaturesmoderntrendsandperspectives AT ayselaslanli combinationofenzymeswithmaterialstogivethemantimicrobialfeaturesmoderntrendsandperspectives AT ilyalyagin combinationofenzymeswithmaterialstogivethemantimicrobialfeaturesmoderntrendsandperspectives AT olgasenko combinationofenzymeswithmaterialstogivethemantimicrobialfeaturesmoderntrendsandperspectives AT olgamaslova combinationofenzymeswithmaterialstogivethemantimicrobialfeaturesmoderntrendsandperspectives |