When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity
Summary: Silver nanomaterials have potent antibacterial properties that are the foundation for their wide commercial use as well as for concerns about their unintended environmental impact. The nanoparticles themselves are relatively biologically inert but they can undergo oxidative dissolution yiel...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222007465 |
| _version_ | 1818244653943619584 |
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| author | Qingbo Zhang Yue Hu Caitlin M. Masterson Wonhee Jang Zhen Xiao Arash Bohloul Daniel Garcia-Rojas Hema L. Puppala George Bennett Vicki L. Colvin |
| author_facet | Qingbo Zhang Yue Hu Caitlin M. Masterson Wonhee Jang Zhen Xiao Arash Bohloul Daniel Garcia-Rojas Hema L. Puppala George Bennett Vicki L. Colvin |
| author_sort | Qingbo Zhang |
| collection | DOAJ |
| description | Summary: Silver nanomaterials have potent antibacterial properties that are the foundation for their wide commercial use as well as for concerns about their unintended environmental impact. The nanoparticles themselves are relatively biologically inert but they can undergo oxidative dissolution yielding toxic silver ions. A quantitative relationship between silver material structure and dissolution, and thus antimicrobial activity, has yet to be established. Here, this dissolution process and associated biological activity is characterized using uniform nanoparticles with variable dimension, shape, and surface chemistry. From this, a phenomenological model emerges that quantitatively relates material structure to both silver dissolution and microbial toxicity. Shape has the most profound influence on antibacterial activity, and surprisingly, surface coatings the least. These results illustrate how material structure may be optimized for antimicrobial properties and suggest strategies for minimizing silver nanoparticle effects on microbes. |
| first_indexed | 2024-12-12T14:20:27Z |
| format | Article |
| id | doaj.art-3ee5ca1ebe2247158d5896e4aff31fab |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-12T14:20:27Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-3ee5ca1ebe2247158d5896e4aff31fab2022-12-22T00:21:47ZengElsevieriScience2589-00422022-07-01257104475When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activityQingbo Zhang0Yue Hu1Caitlin M. Masterson2Wonhee Jang3Zhen Xiao4Arash Bohloul5Daniel Garcia-Rojas6Hema L. Puppala7George Bennett8Vicki L. Colvin9Department of Chemistry and School of Engineering, Brown University, Providence RI 02912, USADepartment of Chemistry and School of Engineering, Brown University, Providence RI 02912, USADepartment of Chemistry and School of Engineering, Brown University, Providence RI 02912, USADepartment of Chemistry, Rice University, Houston, TX 77005, USADepartment of Chemistry and School of Engineering, Brown University, Providence RI 02912, USADepartment of Chemistry, Rice University, Houston, TX 77005, USADepartment of Chemistry, Rice University, Houston, TX 77005, USADepartment of Chemistry, Rice University, Houston, TX 77005, USADepartment of Biosciences, Rice University, Houston, TX 77005, USADepartment of Chemistry and School of Engineering, Brown University, Providence RI 02912, USA; Corresponding authorSummary: Silver nanomaterials have potent antibacterial properties that are the foundation for their wide commercial use as well as for concerns about their unintended environmental impact. The nanoparticles themselves are relatively biologically inert but they can undergo oxidative dissolution yielding toxic silver ions. A quantitative relationship between silver material structure and dissolution, and thus antimicrobial activity, has yet to be established. Here, this dissolution process and associated biological activity is characterized using uniform nanoparticles with variable dimension, shape, and surface chemistry. From this, a phenomenological model emerges that quantitatively relates material structure to both silver dissolution and microbial toxicity. Shape has the most profound influence on antibacterial activity, and surprisingly, surface coatings the least. These results illustrate how material structure may be optimized for antimicrobial properties and suggest strategies for minimizing silver nanoparticle effects on microbes.http://www.sciencedirect.com/science/article/pii/S2589004222007465MicrobiologyNanomaterialsNanoparticlesNanotoxicology |
| spellingShingle | Qingbo Zhang Yue Hu Caitlin M. Masterson Wonhee Jang Zhen Xiao Arash Bohloul Daniel Garcia-Rojas Hema L. Puppala George Bennett Vicki L. Colvin When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity iScience Microbiology Nanomaterials Nanoparticles Nanotoxicology |
| title | When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity |
| title_full | When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity |
| title_fullStr | When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity |
| title_full_unstemmed | When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity |
| title_short | When function is biological: Discerning how silver nanoparticle structure dictates antimicrobial activity |
| title_sort | when function is biological discerning how silver nanoparticle structure dictates antimicrobial activity |
| topic | Microbiology Nanomaterials Nanoparticles Nanotoxicology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222007465 |
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