Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with insulin deficiency due to pancreatic β cell destruction. Multiple independent cohort studies revealed specific lipid spectrum alterations prior to islet autoimmunity in T1DM. Except for serving as building blocks for membrane bioge...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.999108/full |
| _version_ | 1797997043251150848 |
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| author | Jing Zhang Yang Xiao Jingyi Hu Shanshan Liu Zhiguang Zhou Lingxiang Xie |
| author_facet | Jing Zhang Yang Xiao Jingyi Hu Shanshan Liu Zhiguang Zhou Lingxiang Xie |
| author_sort | Jing Zhang |
| collection | DOAJ |
| description | Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with insulin deficiency due to pancreatic β cell destruction. Multiple independent cohort studies revealed specific lipid spectrum alterations prior to islet autoimmunity in T1DM. Except for serving as building blocks for membrane biogenesis, accumulative evidence suggests lipids and their derivatives can also modulate different biological processes in the progression of T1DM, such as inflammation responses, immune attacks, and β cell vulnerability. However, the types of lipids are huge and majority of them have been largely unexplored in T1DM. In this review, based on the lipid classification system, we summarize the clinical evidence on dyslipidemia related to T1DM and elucidate the potential mechanisms by which they participate in regulating inflammation responses, modulating lymphocyte function and influencing β cell susceptibility to apoptosis and dysfunction. This review systematically recapitulates the role and mechanisms of various lipids in T1DM, providing new therapeutic approaches for T1DM from a nutritional perspective. |
| first_indexed | 2024-04-11T10:26:53Z |
| format | Article |
| id | doaj.art-3ee68d02c88c430994beae1468f42eaf |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T10:26:53Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3ee68d02c88c430994beae1468f42eaf2022-12-22T04:29:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.999108999108Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implicationsJing ZhangYang XiaoJingyi HuShanshan LiuZhiguang ZhouLingxiang XieType 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with insulin deficiency due to pancreatic β cell destruction. Multiple independent cohort studies revealed specific lipid spectrum alterations prior to islet autoimmunity in T1DM. Except for serving as building blocks for membrane biogenesis, accumulative evidence suggests lipids and their derivatives can also modulate different biological processes in the progression of T1DM, such as inflammation responses, immune attacks, and β cell vulnerability. However, the types of lipids are huge and majority of them have been largely unexplored in T1DM. In this review, based on the lipid classification system, we summarize the clinical evidence on dyslipidemia related to T1DM and elucidate the potential mechanisms by which they participate in regulating inflammation responses, modulating lymphocyte function and influencing β cell susceptibility to apoptosis and dysfunction. This review systematically recapitulates the role and mechanisms of various lipids in T1DM, providing new therapeutic approaches for T1DM from a nutritional perspective.https://www.frontiersin.org/articles/10.3389/fimmu.2022.999108/fulltype 1 diabetes mellitus (T1DM)dyslipidemiaβ cellinflammationimmunity |
| spellingShingle | Jing Zhang Yang Xiao Jingyi Hu Shanshan Liu Zhiguang Zhou Lingxiang Xie Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications Frontiers in Immunology type 1 diabetes mellitus (T1DM) dyslipidemia β cell inflammation immunity |
| title | Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications |
| title_full | Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications |
| title_fullStr | Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications |
| title_full_unstemmed | Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications |
| title_short | Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications |
| title_sort | lipid metabolism in type 1 diabetes mellitus pathogenetic and therapeutic implications |
| topic | type 1 diabetes mellitus (T1DM) dyslipidemia β cell inflammation immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.999108/full |
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