Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia
Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/7/1413 |
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| author | Rowa Y. Alhabbab Ahdab Alsaieedi Abdullah Algaissi Sara Almahboub Rajaa M. Al-Raddadi Omaima I. Shabouni Rahaf Alhabbab Abdulelah A. Alfaraj Sawsan S. Alamri Najwa D. Aljehani Rwaa H. Abdulal Mohamed A. Alfaleh Turki S. Abujamel Almohanad A. Alkayyal Ahmad Bakur Mahmoud Adel M. Abuzenadah Anwar M. Hashem |
| author_facet | Rowa Y. Alhabbab Ahdab Alsaieedi Abdullah Algaissi Sara Almahboub Rajaa M. Al-Raddadi Omaima I. Shabouni Rahaf Alhabbab Abdulelah A. Alfaraj Sawsan S. Alamri Najwa D. Aljehani Rwaa H. Abdulal Mohamed A. Alfaleh Turki S. Abujamel Almohanad A. Alkayyal Ahmad Bakur Mahmoud Adel M. Abuzenadah Anwar M. Hashem |
| author_sort | Rowa Y. Alhabbab |
| collection | DOAJ |
| description | Healthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of the COVID-19 epidemic in the city of Jeddah, the second largest city in Saudi Arabia, using a cross-sectional analytic study design. Out of 693 participants recruited from 29 June to 10 August 2020, 223 (32.2%, 95% CI: 28.8–35.8) were found to be confirmed seropositive for SARS-CoV-2 antibodies, and among those 197 (88.3%) had never been diagnosed with COVID-19. Seropositivity was not significantly associated with participants reporting COVID-19 compatible symptoms as most seropositive HCW participants 140 (62.8%) were asymptomatic. The large proportion of asymptomatic SARS-CoV-2 cases detected in our study demands periodic testing as a general hospital policy. |
| first_indexed | 2024-03-10T09:19:38Z |
| format | Article |
| id | doaj.art-3ee6927093854d19bde31df8b3c21362 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T09:19:38Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3ee6927093854d19bde31df8b3c213622023-11-22T05:15:37ZengMDPI AGViruses1999-49152021-07-01137141310.3390/v13071413Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi ArabiaRowa Y. Alhabbab0Ahdab Alsaieedi1Abdullah Algaissi2Sara Almahboub3Rajaa M. Al-Raddadi4Omaima I. Shabouni5Rahaf Alhabbab6Abdulelah A. Alfaraj7Sawsan S. Alamri8Najwa D. Aljehani9Rwaa H. Abdulal10Mohamed A. Alfaleh11Turki S. Abujamel12Almohanad A. Alkayyal13Ahmad Bakur Mahmoud14Adel M. Abuzenadah15Anwar M. Hashem16Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi ArabiaVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Community Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaMinistry of Health, Jeddah 23325, Saudi ArabiaDepartment of Oral and Maxillofacial Surgery, King Fahad General Hospital, Jeddah 23325, Saudi ArabiaDepartment of Phlebotomy, Blood Bank & Laboratory, King Fahad General Hospital, Jeddah 23325, Saudi ArabiaVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Medical Laboratory Technology, University of Tabuk, Tabuk 71491, Saudi ArabiaCollege of Applied Medical Sciences, Taibah University, Almadinah Almunwarah 42353, Saudi ArabiaDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi ArabiaVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaHealthcare workers (HCWs) are at high risk for SARS-CoV-2 infection compared to the general population. Here, we aimed to evaluate and characterize the SARS-CoV-2 seropositivity rate in randomly collected samples among HCWs from the largest referral hospitals and quarantine sites during the peak of the COVID-19 epidemic in the city of Jeddah, the second largest city in Saudi Arabia, using a cross-sectional analytic study design. Out of 693 participants recruited from 29 June to 10 August 2020, 223 (32.2%, 95% CI: 28.8–35.8) were found to be confirmed seropositive for SARS-CoV-2 antibodies, and among those 197 (88.3%) had never been diagnosed with COVID-19. Seropositivity was not significantly associated with participants reporting COVID-19 compatible symptoms as most seropositive HCW participants 140 (62.8%) were asymptomatic. The large proportion of asymptomatic SARS-CoV-2 cases detected in our study demands periodic testing as a general hospital policy.https://www.mdpi.com/1999-4915/13/7/1413SARS-CoV-2COVID-19 pandemicanti-S AbsseroprevalenceJeddahHCWs |
| spellingShingle | Rowa Y. Alhabbab Ahdab Alsaieedi Abdullah Algaissi Sara Almahboub Rajaa M. Al-Raddadi Omaima I. Shabouni Rahaf Alhabbab Abdulelah A. Alfaraj Sawsan S. Alamri Najwa D. Aljehani Rwaa H. Abdulal Mohamed A. Alfaleh Turki S. Abujamel Almohanad A. Alkayyal Ahmad Bakur Mahmoud Adel M. Abuzenadah Anwar M. Hashem Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia Viruses SARS-CoV-2 COVID-19 pandemic anti-S Abs seroprevalence Jeddah HCWs |
| title | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
| title_full | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
| title_fullStr | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
| title_full_unstemmed | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
| title_short | Seroprevalence of SARS-CoV-2 Binding and Neutralizing Antibodies in Healthcare Workers during the Epidemic Peak in Referral Hospitals and Quarantine Sites: Saudi Arabia |
| title_sort | seroprevalence of sars cov 2 binding and neutralizing antibodies in healthcare workers during the epidemic peak in referral hospitals and quarantine sites saudi arabia |
| topic | SARS-CoV-2 COVID-19 pandemic anti-S Abs seroprevalence Jeddah HCWs |
| url | https://www.mdpi.com/1999-4915/13/7/1413 |
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