Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction
ABSTRACT Among the cardiovascular diseases (CVD), acute myocardial infarction (AMI) is currently considered the most common cause of death and disability worldwide. Several laboratory tests have been developed for the detection of cardiac injury, including troponins that are considered the gold stan...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Patologia Clínica
2017-10-01
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442017000500305&tlng=en |
| _version_ | 1819282453636841472 |
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| author | Raíssa M. Teixeira Ricardo David Couto |
| author_facet | Raíssa M. Teixeira Ricardo David Couto |
| author_sort | Raíssa M. Teixeira |
| collection | DOAJ |
| description | ABSTRACT Among the cardiovascular diseases (CVD), acute myocardial infarction (AMI) is currently considered the most common cause of death and disability worldwide. Several laboratory tests have been developed for the detection of cardiac injury, including troponins that are considered the gold standard marker (surrogate biomarker) of myocardial injury. The high specificity of troponin for cardiomyocyte necrosis is related to a single unique peptide sequence present in troponin at the cardiac muscle. As a result, studies are currently focused on the development of troponin (hs-cTnI) determination tests with high diagnostic sensitivity value. These diagnostic tests aim to detect increasingly lower serum concentrations of cTnI biomarkers, from the detection of peptide fragments that are released after structural biochemical changes. This article discusses the differences between troponin fragments immunoreactivity to the development of cTnI determination tests, such as the high-sensitivity tests, which arise with the proposal of guaranteeing greater efficiency in the AMI associated diagnosis. |
| first_indexed | 2024-12-24T01:15:50Z |
| format | Article |
| id | doaj.art-3ee6c68899f2489da50f52c27a95520e |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-12-24T01:15:50Z |
| publishDate | 2017-10-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-3ee6c68899f2489da50f52c27a95520e2022-12-21T17:22:46ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742017-10-0153530530810.5935/1676-2444.20170048Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarctionRaíssa M. TeixeiraRicardo David CoutoABSTRACT Among the cardiovascular diseases (CVD), acute myocardial infarction (AMI) is currently considered the most common cause of death and disability worldwide. Several laboratory tests have been developed for the detection of cardiac injury, including troponins that are considered the gold standard marker (surrogate biomarker) of myocardial injury. The high specificity of troponin for cardiomyocyte necrosis is related to a single unique peptide sequence present in troponin at the cardiac muscle. As a result, studies are currently focused on the development of troponin (hs-cTnI) determination tests with high diagnostic sensitivity value. These diagnostic tests aim to detect increasingly lower serum concentrations of cTnI biomarkers, from the detection of peptide fragments that are released after structural biochemical changes. This article discusses the differences between troponin fragments immunoreactivity to the development of cTnI determination tests, such as the high-sensitivity tests, which arise with the proposal of guaranteeing greater efficiency in the AMI associated diagnosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442017000500305&tlng=enacute coronary syndrometroponin Iimmunodominant epitopes |
| spellingShingle | Raíssa M. Teixeira Ricardo David Couto Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction Jornal Brasileiro de Patologia e Medicina Laboratorial acute coronary syndrome troponin I immunodominant epitopes |
| title | Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction |
| title_full | Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction |
| title_fullStr | Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction |
| title_full_unstemmed | Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction |
| title_short | Troponin I (cTnI) fragments immunoreactivity and the development of high-sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction |
| title_sort | troponin i ctni fragments immunoreactivity and the development of high sensitivity diagnostic assays for the associated diagnosis of acute myocardial infarction |
| topic | acute coronary syndrome troponin I immunodominant epitopes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442017000500305&tlng=en |
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