ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF THE HERBAL COMPOSITION ‘HEXAFIT’
The aim of this study was to evaluate the antioxidant activity of herbal medications in order to develop a drug for the treatment of hepatobiliary disorders. We measured total antioxidant activity of the herbal composition ‘Hexafit’ containing flowers of Helichrysum arenarium L. and Tanacetum vulgar...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Private institution educational organization of higher education "Medical University "ReaViz"
2020-11-01
|
| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| Subjects: | |
| Online Access: | https://vestnik.reaviz.ru/jour/article/view/63 |
| _version_ | 1826571451908489216 |
|---|---|
| author | E. V. Ferubko V. N. Zelenkov A. A. Lapin S. D. Litvinov T. D. Dargaeva |
| author_facet | E. V. Ferubko V. N. Zelenkov A. A. Lapin S. D. Litvinov T. D. Dargaeva |
| author_sort | E. V. Ferubko |
| collection | DOAJ |
| description | The aim of this study was to evaluate the antioxidant activity of herbal medications in order to develop a drug for the treatment of hepatobiliary disorders. We measured total antioxidant activity of the herbal composition ‘Hexafit’ containing flowers of Helichrysum arenarium L. and Tanacetum vulgare L., fruits of Rosa sp., leaves of Urtica dioica L. and mint Mentha piperita L., roots of Glycyrrhiza glabra L. and its individual components using coulometric titration. The antioxidant activity of "Hexafit" at a previously established dose of 250 mg/kg was evaluated under experimental conditions of carbon tetrachloride-induced hepatitis; free radical lipid oxidation was assessed using a chemiluminescent assay. We found that that this herbal composition with choleretic action and the plants included in it have antioxidant activity in vitro. For the first time, the experiment demonstrated a synergistic effect of the total antioxidant activity of the composition. We revealed that pharmacotherapy of experimental hepatitis in rats with ‘Hexafit’ ensured a significant decrease in the chemiluminometric parameters of lipids that characterize the intensity of free radical reactions. ‘Hexafit’ has a pronounced inhibitory effect on hyperlipoperoxidemia in the liver of animals with toxic damage. The antioxidant activity of herbal medications can be successfully used for the treatment and prevention of hepatobiliary disorders. |
| first_indexed | 2024-03-12T04:19:47Z |
| format | Article |
| id | doaj.art-3ee6f85abd594ca7b6e705202e618725 |
| institution | Directory Open Access Journal |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| last_indexed | 2025-03-14T12:11:20Z |
| publishDate | 2020-11-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj.art-3ee6f85abd594ca7b6e705202e6187252025-03-02T09:38:08ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792020-11-01039910560ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF THE HERBAL COMPOSITION ‘HEXAFIT’E. V. Ferubko0V. N. Zelenkov1A. A. Lapin2S. D. Litvinov3T. D. Dargaeva4Federal State Budgetary Scientific Institution ‘Russian Research Institute of Medicinal and Aromatic Plants’Federal State Budgetary Scientific Institution ‘Russian Research Institute of Medicinal and Aromatic Plants’; Russian Research Institute of Vegetable GrowingFederal State Budgetary Institution of Higher Education ‘Kazan power engineering University’Private Institution of Higher Education ‘Medical University ‘Reaviz’Federal State Budgetary Scientific Institution ‘Russian Research Institute of Medicinal and Aromatic Plants’The aim of this study was to evaluate the antioxidant activity of herbal medications in order to develop a drug for the treatment of hepatobiliary disorders. We measured total antioxidant activity of the herbal composition ‘Hexafit’ containing flowers of Helichrysum arenarium L. and Tanacetum vulgare L., fruits of Rosa sp., leaves of Urtica dioica L. and mint Mentha piperita L., roots of Glycyrrhiza glabra L. and its individual components using coulometric titration. The antioxidant activity of "Hexafit" at a previously established dose of 250 mg/kg was evaluated under experimental conditions of carbon tetrachloride-induced hepatitis; free radical lipid oxidation was assessed using a chemiluminescent assay. We found that that this herbal composition with choleretic action and the plants included in it have antioxidant activity in vitro. For the first time, the experiment demonstrated a synergistic effect of the total antioxidant activity of the composition. We revealed that pharmacotherapy of experimental hepatitis in rats with ‘Hexafit’ ensured a significant decrease in the chemiluminometric parameters of lipids that characterize the intensity of free radical reactions. ‘Hexafit’ has a pronounced inhibitory effect on hyperlipoperoxidemia in the liver of animals with toxic damage. The antioxidant activity of herbal medications can be successfully used for the treatment and prevention of hepatobiliary disorders.https://vestnik.reaviz.ru/jour/article/view/63herbal medicinesantioxidant activitycoulometric analysischemiluminescent analysis of lipids |
| spellingShingle | E. V. Ferubko V. N. Zelenkov A. A. Lapin S. D. Litvinov T. D. Dargaeva ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF THE HERBAL COMPOSITION ‘HEXAFIT’ Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье herbal medicines antioxidant activity coulometric analysis chemiluminescent analysis of lipids |
| title | ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF THE HERBAL COMPOSITION ‘HEXAFIT’ |
| title_full | ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF THE HERBAL COMPOSITION ‘HEXAFIT’ |
| title_fullStr | ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF THE HERBAL COMPOSITION ‘HEXAFIT’ |
| title_full_unstemmed | ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF THE HERBAL COMPOSITION ‘HEXAFIT’ |
| title_short | ASSESSMENT OF THE ANTIOXIDANT ACTIVITY OF THE HERBAL COMPOSITION ‘HEXAFIT’ |
| title_sort | assessment of the antioxidant activity of the herbal composition hexafit |
| topic | herbal medicines antioxidant activity coulometric analysis chemiluminescent analysis of lipids |
| url | https://vestnik.reaviz.ru/jour/article/view/63 |
| work_keys_str_mv | AT evferubko assessmentoftheantioxidantactivityoftheherbalcompositionhexafit AT vnzelenkov assessmentoftheantioxidantactivityoftheherbalcompositionhexafit AT aalapin assessmentoftheantioxidantactivityoftheherbalcompositionhexafit AT sdlitvinov assessmentoftheantioxidantactivityoftheherbalcompositionhexafit AT tddargaeva assessmentoftheantioxidantactivityoftheherbalcompositionhexafit |