Fasting mimicking diet inhibits tumor-associated macrophage survival and pro-tumor function in hypoxia: implications for combination therapy with anti-angiogenic agent

Fasting mimicking diet inhibits tumor-associated macrophage survival and pro-tumor function in hypoxia: implications for combination therapy with anti-angiogenic agent

Abstract Background Recent research shows that tumor-associated macrophages (TAMs) are the primary consumers of glucose in tumor tissue, surpassing that of tumor cells. Our previous studies revealed that inhibiting glucose uptake impairs the survival and tumor-promoting function of hypoxic TAMs, sug...

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Bibliographic Details
Main Authors: Lei Wang, Yu-jie Wang, Rong Wang, Fu-lian Gong, Yu-huan Shi, Sheng-nan Li, Pan-pan Chen, Yong-fang Yuan
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
Fasting-mimicking diet
Anti-angiogenic drug
Hypoxia
TAMs
Online Access:https://doi.org/10.1186/s12967-023-04577-7

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