Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance
Background: Adults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing, which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular events. It is unknown whether cardiac chronotropic incompetence (CI) during maxi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Journal of Sport and Health Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095254621000193 |
| _version_ | 1827976018363678720 |
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| author | Wouter M.A. Franssen Charly Keytsman Nastasia Marinus Kenneth Verboven Bert O. Eijnde Lisa van Ryckeghem Paul Dendale Renate Zeevaert Guy Massa Dominique Hansen |
| author_facet | Wouter M.A. Franssen Charly Keytsman Nastasia Marinus Kenneth Verboven Bert O. Eijnde Lisa van Ryckeghem Paul Dendale Renate Zeevaert Guy Massa Dominique Hansen |
| author_sort | Wouter M.A. Franssen |
| collection | DOAJ |
| description | Background: Adults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing, which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular events. It is unknown whether cardiac chronotropic incompetence (CI) during maximal exercise is already present in obese adolescents and, if so, how that relates to cardiometabolic health. Methods: Sixty-nine obese adolescents (body mass index standard deviation score = 2.23 ± 0.32, age = 14.1 ± 1.2 years; mean ± SD) and 29 lean adolescents (body mass index standard deviation score = –0.16 ± 0.84, age = 14.0 ± 1.5 years) performed a maximal cardiopulmonary exercise testing from which indicators for peak performance were determined. The resting heart rate and peak heart rate were used to calculate the maximal chronotropic response index. Biochemistry (lipid profile, glycemic control, inflammation, and leptin) was studied in fasted blood samples and during an oral glucose tolerance test within obese adolescents. Regression analyses were applied to examine associations between the presence of CI and blood or exercise capacity parameters, respectively, within obese adolescents. Results: CI was prevalent in 32 out of 69 obese adolescents (46%) and 3 out of 29 lean adolescents (10%). C-reactive protein was significantly higher in obese adolescents with CI compared to obese adolescents without CI (p = 0.012). Furthermore, peak oxygen uptake and peak cycling power output were significantly reduced (p < 0.05) in obese adolescents with CI vs. obese adolescents without CI. The chronotropic index was independently related to blood total cholesterol (standardized coefficient β = –0.332; p = 0.012) and C-reactive protein concentration (standardized coefficient β = –0.269; p = 0.039). Conclusion: CI is more common in the current cohort of obese adolescents, and is related to systemic inflammation and exercise intolerance. |
| first_indexed | 2024-04-09T20:20:44Z |
| format | Article |
| id | doaj.art-3ee83f3bc4e44323ad6576138e011e50 |
| institution | Directory Open Access Journal |
| issn | 2095-2546 |
| language | English |
| last_indexed | 2024-04-09T20:20:44Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Sport and Health Science |
| spelling | doaj.art-3ee83f3bc4e44323ad6576138e011e502023-03-31T05:53:00ZengElsevierJournal of Sport and Health Science2095-25462023-03-01122194201Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intoleranceWouter M.A. Franssen0Charly Keytsman1Nastasia Marinus2Kenneth Verboven3Bert O. Eijnde4Lisa van Ryckeghem5Paul Dendale6Renate Zeevaert7Guy Massa8Dominique Hansen9Rehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences, Hasselt University, Hasselt 3500, Belgium; Biomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences, Hasselt University, Hasselt 3500, Belgium; Corresponding author.Rehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences, Hasselt University, Hasselt 3500, Belgium; Biomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences, Hasselt University, Hasselt 3500, BelgiumRehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences, Hasselt University, Hasselt 3500, BelgiumRehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences, Hasselt University, Hasselt 3500, Belgium; Biomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences, Hasselt University, Hasselt 3500, BelgiumBiomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences, Hasselt University, Hasselt 3500, Belgium; ADLON Sports Medical Center, Hasselt 3500, BelgiumRehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences, Hasselt University, Hasselt 3500, Belgium; Biomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences, Hasselt University, Hasselt 3500, BelgiumBiomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences, Hasselt University, Hasselt 3500, Belgium; Heart Centre Hasselt, Jessa Hospital, Hasselt 3500, BelgiumDepartment of Pediatric Endocrinology and Diabetology, Jessa Hospital, Hasselt 3500, BelgiumBiomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences, Hasselt University, Hasselt 3500, Belgium; Department of Pediatric Endocrinology and Diabetology, Jessa Hospital, Hasselt 3500, BelgiumRehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences, Hasselt University, Hasselt 3500, Belgium; Biomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences, Hasselt University, Hasselt 3500, Belgium; Heart Centre Hasselt, Jessa Hospital, Hasselt 3500, BelgiumBackground: Adults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing, which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular events. It is unknown whether cardiac chronotropic incompetence (CI) during maximal exercise is already present in obese adolescents and, if so, how that relates to cardiometabolic health. Methods: Sixty-nine obese adolescents (body mass index standard deviation score = 2.23 ± 0.32, age = 14.1 ± 1.2 years; mean ± SD) and 29 lean adolescents (body mass index standard deviation score = –0.16 ± 0.84, age = 14.0 ± 1.5 years) performed a maximal cardiopulmonary exercise testing from which indicators for peak performance were determined. The resting heart rate and peak heart rate were used to calculate the maximal chronotropic response index. Biochemistry (lipid profile, glycemic control, inflammation, and leptin) was studied in fasted blood samples and during an oral glucose tolerance test within obese adolescents. Regression analyses were applied to examine associations between the presence of CI and blood or exercise capacity parameters, respectively, within obese adolescents. Results: CI was prevalent in 32 out of 69 obese adolescents (46%) and 3 out of 29 lean adolescents (10%). C-reactive protein was significantly higher in obese adolescents with CI compared to obese adolescents without CI (p = 0.012). Furthermore, peak oxygen uptake and peak cycling power output were significantly reduced (p < 0.05) in obese adolescents with CI vs. obese adolescents without CI. The chronotropic index was independently related to blood total cholesterol (standardized coefficient β = –0.332; p = 0.012) and C-reactive protein concentration (standardized coefficient β = –0.269; p = 0.039). Conclusion: CI is more common in the current cohort of obese adolescents, and is related to systemic inflammation and exercise intolerance.http://www.sciencedirect.com/science/article/pii/S2095254621000193AdolescentsCardiometabolic healthExercise toleranceHeart rateObesity |
| spellingShingle | Wouter M.A. Franssen Charly Keytsman Nastasia Marinus Kenneth Verboven Bert O. Eijnde Lisa van Ryckeghem Paul Dendale Renate Zeevaert Guy Massa Dominique Hansen Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance Journal of Sport and Health Science Adolescents Cardiometabolic health Exercise tolerance Heart rate Obesity |
| title | Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance |
| title_full | Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance |
| title_fullStr | Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance |
| title_full_unstemmed | Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance |
| title_short | Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance |
| title_sort | chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance |
| topic | Adolescents Cardiometabolic health Exercise tolerance Heart rate Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2095254621000193 |
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