TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes

TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes

TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS). Previous studies have demonstrated that loss of TDP-43 function leads to intracellular accumulation of non-coding repetitive element transcripts an...

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Bibliographic Details
Main Authors:	Thomas J. LaRocca, Andrea Mariani, Linda R. Watkins, Christopher D. Link
Format:	Article
Language:	English
Published:	Elsevier 2019-12-01
Series:	Neurobiology of Disease
Subjects:	TDP-43 Amyotrophic lateral sclerosis Reactive astrocytes Protein kinase R
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996119301731

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