Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4370497?pdf=render |
| _version_ | 1819261966882963456 |
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| author | Lydia Herrmann Caspar Wiegmann Annika Arsalan-Werner Isabel Hilbrich Carsten Jäger Katharina Flach Anne Suttkus Ingolf Lachmann Thomas Arendt Max Holzer |
| author_facet | Lydia Herrmann Caspar Wiegmann Annika Arsalan-Werner Isabel Hilbrich Carsten Jäger Katharina Flach Anne Suttkus Ingolf Lachmann Thomas Arendt Max Holzer |
| author_sort | Lydia Herrmann |
| collection | DOAJ |
| description | Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes. Furthermore, Hook proteins are associated with pathological hallmarks in AD; Hook1 and Hook3 are localized to tau aggregates and Hook2 to glial components within amyloid plaques. Additionally, the expression of Hook3 is reduced in AD. Modelling of Hook3 deficiency in cultured cells leads to slowing of endosomal transport and increases β-amyloid production. We propose that Hook3 plays a role in pathogenic events exacerbating AD. |
| first_indexed | 2024-12-23T19:50:12Z |
| format | Article |
| id | doaj.art-3eecbc427092408e831b63c51935cfc7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T19:50:12Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3eecbc427092408e831b63c51935cfc72022-12-21T17:33:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011942310.1371/journal.pone.0119423Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.Lydia HerrmannCaspar WiegmannAnnika Arsalan-WernerIsabel HilbrichCarsten JägerKatharina FlachAnne SuttkusIngolf LachmannThomas ArendtMax HolzerDefects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes. Furthermore, Hook proteins are associated with pathological hallmarks in AD; Hook1 and Hook3 are localized to tau aggregates and Hook2 to glial components within amyloid plaques. Additionally, the expression of Hook3 is reduced in AD. Modelling of Hook3 deficiency in cultured cells leads to slowing of endosomal transport and increases β-amyloid production. We propose that Hook3 plays a role in pathogenic events exacerbating AD.http://europepmc.org/articles/PMC4370497?pdf=render |
| spellingShingle | Lydia Herrmann Caspar Wiegmann Annika Arsalan-Werner Isabel Hilbrich Carsten Jäger Katharina Flach Anne Suttkus Ingolf Lachmann Thomas Arendt Max Holzer Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. PLoS ONE |
| title | Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. |
| title_full | Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. |
| title_fullStr | Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. |
| title_full_unstemmed | Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. |
| title_short | Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. |
| title_sort | hook proteins association with alzheimer pathology and regulatory role of hook3 in amyloid beta generation |
| url | http://europepmc.org/articles/PMC4370497?pdf=render |
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