Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly...

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Bibliographic Details
Main Authors: Lydia Herrmann, Caspar Wiegmann, Annika Arsalan-Werner, Isabel Hilbrich, Carsten Jäger, Katharina Flach, Anne Suttkus, Ingolf Lachmann, Thomas Arendt, Max Holzer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370497?pdf=render

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