Roles and Mechanisms of the Protein Quality Control System in Alzheimer’s Disease

Roles and Mechanisms of the Protein Quality Control System in Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by the deposition of senile plaques (SPs) and the formation of neurofibrillary tangles (NTFs), as well as neuronal dysfunctions in the brain, but in fact, patients have shown a sustained disease progression for at least 10 to 15 years before these pathologic...

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Bibliographic Details
Main Authors: Yaping Liu, Runrong Ding, Ze Xu, Yuan Xue, Dongdong Zhang, Yujing Zhang, Wenjie Li, Xing Li
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
protein quality control
endoplasmic reticulum stress
autophagy–lysosome
ubiquitin–proteasome
Online Access:https://www.mdpi.com/1422-0067/23/1/345

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