An Integrated Mass Spectrometry-Based Glycomics-Driven Glycoproteomics Analytical Platform to Functionally Characterize Glycosylation Inhibitors

An Integrated Mass Spectrometry-Based Glycomics-Driven Glycoproteomics Analytical Platform to Functionally Characterize Glycosylation Inhibitors

Cancer progression is linked to aberrant protein glycosylation due to the overexpression of several glycosylation enzymes. These enzymes are underexploited as potential anticancer drug targets and the development of rapid-screening methods and identification of glycosylation inhibitors are highly so...

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Bibliographic Details
Main Authors: Michael Russelle S. Alvarez, Qingwen Zhou, Sheryl Joyce B. Grijaldo, Carlito B. Lebrilla, Ruel C. Nacario, Francisco M. Heralde, Jomar F. Rabajante, Gladys C. Completo
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
glycomics
glycoproteomics
glycosylation
proteomics
in silico docking
network pharmacology
Online Access:https://www.mdpi.com/1420-3049/27/12/3834

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