Therapy of reprogrammable immune activating supramolecular-based chitosan membranes for skin regeneration
Immune cells play an important role in the inflammatory and proliferative stages of diabetes skin defect. How to regulate immune response is the key to skin regeneration. To address this challenge, we developed chitosan polymer membrane (CM) to directly deliver solamarine (Sol) for targeting reactiv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523001284 |
| _version_ | 1797853976316608512 |
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| author | ShuRui Chen Jinpeng Gao Xiang Luo Yu Sun Wen Jin Rongrong He |
| author_facet | ShuRui Chen Jinpeng Gao Xiang Luo Yu Sun Wen Jin Rongrong He |
| author_sort | ShuRui Chen |
| collection | DOAJ |
| description | Immune cells play an important role in the inflammatory and proliferative stages of diabetes skin defect. How to regulate immune response is the key to skin regeneration. To address this challenge, we developed chitosan polymer membrane (CM) to directly deliver solamarine (Sol) for targeting reactive oxygen species (ROS)-enriched microenvironment. The Sol-loaded CM (Sol-CM) inhibits the excessive recruitment of inflammatory cells, and polarizes macrophages into an anti-inflammatory phenotype “M2″ to inhibit excessive inflammatory response. Therefore, the Sol-CM can help maintain immune homoeostasis, which contributes to the pathogenesis of wound. The Sol-CM demonstrated excellent therapeutic efficacy in treating wound. In addition, Sol-CM significantly attenuates focal inflammation and fibrosis level, thus potentially leading to a highly innovative and translational approach to treat diabetic wound efficiently and safely. |
| first_indexed | 2024-04-09T19:58:25Z |
| format | Article |
| id | doaj.art-3ef11750c481448c917c64a26792739b |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-09T19:58:25Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-3ef11750c481448c917c64a26792739b2023-04-03T05:20:46ZengElsevierMaterials & Design0264-12752023-03-01227111713Therapy of reprogrammable immune activating supramolecular-based chitosan membranes for skin regenerationShuRui Chen0Jinpeng Gao1Xiang Luo2Yu Sun3Wen Jin4Rongrong He5Cardiac Intensive Care Unit, Cardiovascular Hospital, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, China; Integrated Chinese and Western Medicine Postdoctoral Research Station, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Orthopedic, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaCardiac Intensive Care Unit, Cardiovascular Hospital, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, China; Integrated Chinese and Western Medicine Postdoctoral Research Station, School of Medicine, Jinan University, Guangzhou, ChinaCardiac Intensive Care Unit, Cardiovascular Hospital, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, ChinaCardiac Intensive Care Unit, Cardiovascular Hospital, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, China; Corresponding authors at: Cardiac Intensive Care Unit, Cardiovascular Hospital, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, China (R. He).Cardiac Intensive Care Unit, Cardiovascular Hospital, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, China; Integrated Chinese and Western Medicine Postdoctoral Research Station, School of Medicine, Jinan University, Guangzhou, China; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou, China; Corresponding authors at: Cardiac Intensive Care Unit, Cardiovascular Hospital, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, China (R. He).Immune cells play an important role in the inflammatory and proliferative stages of diabetes skin defect. How to regulate immune response is the key to skin regeneration. To address this challenge, we developed chitosan polymer membrane (CM) to directly deliver solamarine (Sol) for targeting reactive oxygen species (ROS)-enriched microenvironment. The Sol-loaded CM (Sol-CM) inhibits the excessive recruitment of inflammatory cells, and polarizes macrophages into an anti-inflammatory phenotype “M2″ to inhibit excessive inflammatory response. Therefore, the Sol-CM can help maintain immune homoeostasis, which contributes to the pathogenesis of wound. The Sol-CM demonstrated excellent therapeutic efficacy in treating wound. In addition, Sol-CM significantly attenuates focal inflammation and fibrosis level, thus potentially leading to a highly innovative and translational approach to treat diabetic wound efficiently and safely.http://www.sciencedirect.com/science/article/pii/S0264127523001284SupramolecularChitosan membranesDrug releaseSkin regenerationImmune responseMacrophages |
| spellingShingle | ShuRui Chen Jinpeng Gao Xiang Luo Yu Sun Wen Jin Rongrong He Therapy of reprogrammable immune activating supramolecular-based chitosan membranes for skin regeneration Materials & Design Supramolecular Chitosan membranes Drug release Skin regeneration Immune response Macrophages |
| title | Therapy of reprogrammable immune activating supramolecular-based chitosan membranes for skin regeneration |
| title_full | Therapy of reprogrammable immune activating supramolecular-based chitosan membranes for skin regeneration |
| title_fullStr | Therapy of reprogrammable immune activating supramolecular-based chitosan membranes for skin regeneration |
| title_full_unstemmed | Therapy of reprogrammable immune activating supramolecular-based chitosan membranes for skin regeneration |
| title_short | Therapy of reprogrammable immune activating supramolecular-based chitosan membranes for skin regeneration |
| title_sort | therapy of reprogrammable immune activating supramolecular based chitosan membranes for skin regeneration |
| topic | Supramolecular Chitosan membranes Drug release Skin regeneration Immune response Macrophages |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523001284 |
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