The incidence, mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency department
<h4>Background</h4> Acute kidney injury (AKI) is a major health problem associated with considerable mortality and morbidity. Studies on clinical outcomes and mortality of AKI in the emergency department are scarce. The aim of this study is to assess incidence, mortality and renal outcom...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654152/?tool=EBI |
| _version_ | 1819181087248613376 |
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| author | Meriem Khairoun Jan Willem Uffen Gurbey Ocak Romy Koopsen Saskia Haitjema Jan Jelrik Oosterheert Karin Kaasjager |
| author_facet | Meriem Khairoun Jan Willem Uffen Gurbey Ocak Romy Koopsen Saskia Haitjema Jan Jelrik Oosterheert Karin Kaasjager |
| author_sort | Meriem Khairoun |
| collection | DOAJ |
| description | <h4>Background</h4> Acute kidney injury (AKI) is a major health problem associated with considerable mortality and morbidity. Studies on clinical outcomes and mortality of AKI in the emergency department are scarce. The aim of this study is to assess incidence, mortality and renal outcomes after AKI in patients with suspected infection at the emergency department. <h4>Methods</h4> We used data from the SPACE-cohort (SePsis in the ACutely ill patients in the Emergency department), which included consecutive patients that presented to the emergency department of the internal medicine with suspected infection. Hazard ratios (HR) were assessed using Cox regression to investigate the association between AKI, 30-days mortality and renal function decline up to 1 year after AKI. Survival in patients with and without AKI was assessed using Kaplan-Meier analyses. <h4>Results</h4> Of the 3105 patients in the SPACE-cohort, we included 1716 patients who fulfilled the inclusion criteria. Of these patients, 10.8% had an AKI episode. Mortality was 12.4% for the AKI group and 4.2% for the non-AKI patients. The adjusted HR for all-cause mortality at 30-days in AKI patients was 2.8 (95% CI 1.7–4.8). Moreover, the cumulative incidence of renal function decline was 69.8% for AKI patients and 39.3% for non-AKI patients. Patients with an episode of AKI had higher risk of developing renal function decline (adjusted HR 3.3, 95% CI 2.4–4.5) at one year after initial AKI-episode at the emergency department. <h4>Conclusion</h4> Acute kidney injury is common in patients with suspected infection in the emergency department and is significantly associated with 30-days mortality and renal function decline one year after AKI. |
| first_indexed | 2024-12-22T22:24:39Z |
| format | Article |
| id | doaj.art-3ef1f61ea48749af8840521f228ecac0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T22:24:39Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3ef1f61ea48749af8840521f228ecac02022-12-21T18:10:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612The incidence, mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency departmentMeriem KhairounJan Willem UffenGurbey OcakRomy KoopsenSaskia HaitjemaJan Jelrik OosterheertKarin Kaasjager<h4>Background</h4> Acute kidney injury (AKI) is a major health problem associated with considerable mortality and morbidity. Studies on clinical outcomes and mortality of AKI in the emergency department are scarce. The aim of this study is to assess incidence, mortality and renal outcomes after AKI in patients with suspected infection at the emergency department. <h4>Methods</h4> We used data from the SPACE-cohort (SePsis in the ACutely ill patients in the Emergency department), which included consecutive patients that presented to the emergency department of the internal medicine with suspected infection. Hazard ratios (HR) were assessed using Cox regression to investigate the association between AKI, 30-days mortality and renal function decline up to 1 year after AKI. Survival in patients with and without AKI was assessed using Kaplan-Meier analyses. <h4>Results</h4> Of the 3105 patients in the SPACE-cohort, we included 1716 patients who fulfilled the inclusion criteria. Of these patients, 10.8% had an AKI episode. Mortality was 12.4% for the AKI group and 4.2% for the non-AKI patients. The adjusted HR for all-cause mortality at 30-days in AKI patients was 2.8 (95% CI 1.7–4.8). Moreover, the cumulative incidence of renal function decline was 69.8% for AKI patients and 39.3% for non-AKI patients. Patients with an episode of AKI had higher risk of developing renal function decline (adjusted HR 3.3, 95% CI 2.4–4.5) at one year after initial AKI-episode at the emergency department. <h4>Conclusion</h4> Acute kidney injury is common in patients with suspected infection in the emergency department and is significantly associated with 30-days mortality and renal function decline one year after AKI.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654152/?tool=EBI |
| spellingShingle | Meriem Khairoun Jan Willem Uffen Gurbey Ocak Romy Koopsen Saskia Haitjema Jan Jelrik Oosterheert Karin Kaasjager The incidence, mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency department PLoS ONE |
| title | The incidence, mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency department |
| title_full | The incidence, mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency department |
| title_fullStr | The incidence, mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency department |
| title_full_unstemmed | The incidence, mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency department |
| title_short | The incidence, mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency department |
| title_sort | incidence mortality and renal outcomes of acute kidney injury in patients with suspected infection at the emergency department |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654152/?tool=EBI |
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