Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast

Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast

<p>Abstract</p> <p>Background</p> <p>The ability of cytosine deaminase (CD) to convert the antifungal agent 5-fluorocytosine (5-FC) into one of the most potent and largely used anticancer compound such as 5-fluorouracil (5-FU) raised considerable interest in this enzyme...

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Main Authors: Tombesi Marina, Gellini Mara, Ascione Alessandro, Flego Michela, Santoro Filippo, Carpinelli Giulia, Zamboni Silvia, Mallano Alessandra, Podo Franca, Cianfriglia Maurizio
Format: Article
Language:English
Published: BMC 2008-09-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/8/68

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