Interest of Fluvoxamine as an Add-On to Clozapine in Children With Severe Psychiatric Disorder According to CYP Polymorphisms: Experience From a Case Series

Interest of Fluvoxamine as an Add-On to Clozapine in Children With Severe Psychiatric Disorder According to CYP Polymorphisms: Experience From a Case Series

Despite its drastic efficacy in resistant psychiatric disorders, clozapine remains rarely used in youth due to its side effects. Clozapine plasma level is determined through its metabolism involving several isoforms of cytochromes 450 (CYP450) family. Isoform CYP1A2 appears as a limiting enzyme invo...

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Bibliographic Details
Main Authors: Camille Berel, Ulysse Mossé, Julien Wils, Lauriane Cousin, Laurent Imbert, Priscille Gerardin, Boris Chaumette, Fabien Lamoureux, Vladimir Ferrafiat
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Psychiatry
Subjects:
clozapine
resistant psychiatric disorder
child and adolescent psychiatry
cytochrome polymorphism
fluvoxamine
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.669446/full

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