Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 Tesla
Abstract Background The value of apparent diffusion coefficient (ADC) values and quantitative parameters (Ktrans, Kep, Ve) in detecting prognostic factor at 3.0 Tesla remains unclear, especially in predicting prognosis of breast cancer. Methods A total of 151 patients with IDC underwent breast DCE-M...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-12-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-018-1538-8 |
| _version_ | 1811326926035353600 |
|---|---|
| author | Fei Liu Mei Wang Haige Li |
| author_facet | Fei Liu Mei Wang Haige Li |
| author_sort | Fei Liu |
| collection | DOAJ |
| description | Abstract Background The value of apparent diffusion coefficient (ADC) values and quantitative parameters (Ktrans, Kep, Ve) in detecting prognostic factor at 3.0 Tesla remains unclear, especially in predicting prognosis of breast cancer. Methods A total of 151 patients with IDC underwent breast DCE-MRI and DWI-MRI at 3.0 Tesla following surgery. The ADC values were acquired with b values of 0 and 1000 s/mm2. The relationship between ADC values or DCE-MRI quantitative parameters and size, histologic grade (HG), lymph node metastasis (LNM), ER, PR, and Ki67 was evaluated. The predictive values of ADC, Ktrans, Kep, and Ve to prognosis of IDC were assessed. Results ADC value was positively related to size (P = 0.04) and HER2 (P = 0.046) expression and negatively related to ER (P = 0.012) and PR (P < 0.001) expression. Ktrans value has positive correlation with size (P < 0.001), HG (P < 0.001), LNM (P < 0.001), HER2 (P = 0.007), and Ki67 (P < 0.001) expression and negative correlation with ER (P < 0.001) and PR (P < 0.001) expression. Kep value was positively related to size (P < 0.001) and negatively related to ER (P < 0.001) and PR (P < 0.001) expression. Ve value was negatively related to HER2 expression (P = 0.004). The Cox hazard ratio (HR) of ADC, Ktrans, Kep, and Ve values on survival was 5.26 (P = 0.093), 1.081 (P = 0.002), 1.006 (P = 0.941), and 0.883 (P = 0.926), respectively. Conclusions Ktrans value was a best predictive indicator of HG, LNM, ER, PR, and Ki67 expression, and ADC value was the best predictive indicator of HER2. Preoperative use of the 3.0 Tesla could provide important information to determine the optimal treatment plan. |
| first_indexed | 2024-04-13T14:57:53Z |
| format | Article |
| id | doaj.art-3efa5eece7db4b3aaa848401a6df6158 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-13T14:57:53Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-3efa5eece7db4b3aaa848401a6df61582022-12-22T02:42:23ZengBMCWorld Journal of Surgical Oncology1477-78192018-12-0116111210.1186/s12957-018-1538-8Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 TeslaFei Liu0Mei Wang1Haige Li2Department of Medical Imaging, The Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Medical Imaging, The Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Medical Imaging, The Second Affiliated Hospital of Nanjing Medical UniversityAbstract Background The value of apparent diffusion coefficient (ADC) values and quantitative parameters (Ktrans, Kep, Ve) in detecting prognostic factor at 3.0 Tesla remains unclear, especially in predicting prognosis of breast cancer. Methods A total of 151 patients with IDC underwent breast DCE-MRI and DWI-MRI at 3.0 Tesla following surgery. The ADC values were acquired with b values of 0 and 1000 s/mm2. The relationship between ADC values or DCE-MRI quantitative parameters and size, histologic grade (HG), lymph node metastasis (LNM), ER, PR, and Ki67 was evaluated. The predictive values of ADC, Ktrans, Kep, and Ve to prognosis of IDC were assessed. Results ADC value was positively related to size (P = 0.04) and HER2 (P = 0.046) expression and negatively related to ER (P = 0.012) and PR (P < 0.001) expression. Ktrans value has positive correlation with size (P < 0.001), HG (P < 0.001), LNM (P < 0.001), HER2 (P = 0.007), and Ki67 (P < 0.001) expression and negative correlation with ER (P < 0.001) and PR (P < 0.001) expression. Kep value was positively related to size (P < 0.001) and negatively related to ER (P < 0.001) and PR (P < 0.001) expression. Ve value was negatively related to HER2 expression (P = 0.004). The Cox hazard ratio (HR) of ADC, Ktrans, Kep, and Ve values on survival was 5.26 (P = 0.093), 1.081 (P = 0.002), 1.006 (P = 0.941), and 0.883 (P = 0.926), respectively. Conclusions Ktrans value was a best predictive indicator of HG, LNM, ER, PR, and Ki67 expression, and ADC value was the best predictive indicator of HER2. Preoperative use of the 3.0 Tesla could provide important information to determine the optimal treatment plan.http://link.springer.com/article/10.1186/s12957-018-1538-8Diffusion-weighted MRIMagnetic resonance imagingInvasive ductal carcinomaBreast cancer |
| spellingShingle | Fei Liu Mei Wang Haige Li Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 Tesla World Journal of Surgical Oncology Diffusion-weighted MRI Magnetic resonance imaging Invasive ductal carcinoma Breast cancer |
| title | Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 Tesla |
| title_full | Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 Tesla |
| title_fullStr | Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 Tesla |
| title_full_unstemmed | Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 Tesla |
| title_short | Role of perfusion parameters on DCE-MRI and ADC values on DWMRI for invasive ductal carcinoma at 3.0 Tesla |
| title_sort | role of perfusion parameters on dce mri and adc values on dwmri for invasive ductal carcinoma at 3 0 tesla |
| topic | Diffusion-weighted MRI Magnetic resonance imaging Invasive ductal carcinoma Breast cancer |
| url | http://link.springer.com/article/10.1186/s12957-018-1538-8 |
| work_keys_str_mv | AT feiliu roleofperfusionparametersondcemriandadcvaluesondwmriforinvasiveductalcarcinomaat30tesla AT meiwang roleofperfusionparametersondcemriandadcvaluesondwmriforinvasiveductalcarcinomaat30tesla AT haigeli roleofperfusionparametersondcemriandadcvaluesondwmriforinvasiveductalcarcinomaat30tesla |